Results 61 to 70 of about 1,740,047 (309)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Cell death and life in cancer: mathematical modeling of cell fate decisions

, 2011
Tumor development is characterized by a compromised balance between cell life and death decision mechanisms, which are tighly regulated in normal cells.
Barillot, Emmanuel, Calzone, Laurence, Fourquet, Simon, Tournier, Laurent, Zinovyev, Andrei   +4 more
core   +2 more sources

Increase in Tomato Locule Number Is Controlled by Two Single-Nucleotide Polymorphisms Located [PDF]

, 2011
In tomato (Solanum lycopersicum) fruit, the number of locules (cavities containing seeds that are derived from carpels) varies from two to up to 10 or more.
Berard, Aurélie, Botton, Emmanuel, Bouzayen, Mondher, Brunel, Dominique, Carretero, Yolande, Causse, Mathilde, Delalande, Corinne, Duffe, Philippe, Le Paslier, Marie-Christine, Munos, Stéphane, Ranc, Nicolas, Rolland, Sophie   +11 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

APPROACHES TO ANALYSIS OF GENOTYPE AND PHENOTYPE RELATION WITH QTL METHODS [PDF]

Научно-технический вестник информационных технологий, механики и оптики, 2018
The paper describes methods of QTL-analysis in the research of the genotype influence. QTL-analysis is a statistical method that connects phenotypic data with genotype, enables the determination of the exact localization and gene influence power. The QTL
Furta E.Yu., Shabalina I.M.
doaj   +1 more source

From network to phenotype : the dynamic wiring of an Arabidopsis transcriptional network induced by osmotic stress [PDF]

, 2017
Plants have established different mechanisms to cope with environmental fluctuations and accordingly fine-tune their growth and development through the regulation of complex molecular networks.
Dirk Inzé, Lisa Van den Broeck, Marieke Dubois, Mattias Vermeersch, Minami Matsui, R Core Team, Veronique Storme, Zhou X   +7 more
core   +1 more source

Plant Proteases: From Phenotypes to Molecular Mechanisms [PDF]

Annual Review of Plant Biology, 2008
Plant genomes encode hundreds of proteases, which represent dozens of unrelated families. The biological role of these proteases is mostly unknown, but mutant alleles, gene silencing, and overexpression studies have provided phenotypes for a growing number of proteases. The aim of this review is to show the diversity of the processes that are regulated
openaire   +5 more sources

Clinical and Molecular Phenotype of Aicardi-Goutières Syndrome [PDF]

The American Journal of Human Genetics, 2007
Aicardi-Goutieres syndrome (AGS) is a genetic encephalopathy whose clinical features mimic those of acquired in utero viral infection. AGS exhibits locus heterogeneity, with mutations identified in genes encoding the 3'-->5' exonuclease TREX1 and the three subunits of the RNASEH2 endonuclease complex.
Rice, Gillian, Patrick, Teresa, Parmar, Rekha, Taylor, Claire F., Aeby, Alec, Aicardi, Jean, Artuch, Rafael, Montalto, Simon Attard, Bacino, Carlos A., Barroso, Bruno, Baxter, Peter, Benko, Willam S., Bergmann, Carsten, Bertini, Enrico, Biancheri, Roberta, Blair, Edward M., Blau, Nenad, Bonthron, David T., Briggs, Tracy, Brueton, Louise A., Brunner, Han G., Burke, Christopher J., Carr, Ian M., Carvalho, Daniel R., Chandler, Kate E., Christen, Hans-Jurgen, Corry, Peter C., Cowan, Frances M., Cox, Helen, D'Arrigo, Stefano, Dean, John, de Laet, Corinne, de Praeter, Claudine, Dery, Catherine, Ferrie, Colin D., Flintoff, Kim, Frints, Suzanna G. M., Garcia-Cazorla, Angels, Gener, Blanca, Goizet, Cyril, Goutieres, Francoise, Green, Andrew J., Guet, Agnes, Hamel, Ben C. J., Hayward, Bruce E., Heiberg, Arvid, Hennekam, Raoul C., Husson, Marie, Jackson, Andrew P., Jayatunga, Rasieka, Jiang, Yong-Hui, Kant, Sarina G., Kao, Amy, King, Mary D., Kingston, Helen M., Klepper, Joerg, van der Knaap, Marjo S., Kornberg, Andrew J., Kotzot, Dieter, Kratzer, Wilfried, Lacombe, Didier, Lagae, Lieven, Landrieu, Pierre Georges, Lanzi, Giovanni, Leitch, Andrea, Lim, Ming J., Livingston, John H., Lourenco, Charles M., Lyall, E. G. Hermione, Lynch, Sally A., Lyons, Michael J., Marom, Daphna, McClure, John P., McWilliam, Robert, Melancon, Serge B., Mewasingh, Leena D., Moutard, Marie-Laure, Nischal, Ken K., Ostergaard, John R., Prendiville, Julie, Rasmussen, Magnhild, Rogers, R. Curtis, Roland, Dominique, Rosser, Elisabeth M., Rostasy, Kevin, Roubertie, Agathe, Sanchis, Amparo, Schiffmann, Raphael, Scholl-Burgi, Sabine, Seal, Sunita, Shalev, Stavit A., Corcoles, C. Sierra, Sinha, Gyan P., Soler, Doriette, Spiegel, Ronen, Stephenson, John B. P., Tacke, Uta, Tan, Tiong Yang, Till, Marianne, Tolmie, John L., Tomlin, Pam, Vagnarelli, Federica, Valente, Enza Maria, van Coster, Rudy N. A., van der Aa, Nathalie, Vanderver, Adeline, Vles, Johannes S. H., Voit, Thomas, Wassmer, Evangeline, Weschke, Bernhard, Whiteford, Margo L., Willemsen, Michel A. A., Zankl, Andreas, Zuberi, Sameer M., Orcesi, Simona, Fazzi, Elisa, Lebon, Pierre, Crow, Yanick J., Østergaard, John R., Tiong, Yang Tan   +119 more
openaire   +10 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The Multifaceted Activity of the VirF Regulatory Protein in the Shigella Lifestyle [PDF]

, 2016
Shigella is a highly adapted human pathogen, mainly found in the developing world and causing a severe enteric syndrome. The highly sophisticated infectious strategy of Shigella banks on the capacity to invade the intestinal epithelial barrier and cause ...
Colonna, Bianca, DI MARTINO, MARIA LETIZIA, Falconi, Maurizio, Micheli, Gioacchino, Prosseda, Gianni   +4 more
core   +3 more sources