Virus-induced gene silencing database for phenomics and functional genomics in Nicotiana benthamiana [PDF]
, 2018 Virus-induced gene silencing (VIGS) is an important forward and reverse genetics method for the study of gene function in many plant species, especially Nicotiana benthamiana.
Chakravarthy, Suma +15 more
core +2 more sources
Drug repositioning by kernel-based integration of molecular structure, molecular activity, and phenotype data. [PDF]
PLoS ONE, 2013 Computational inference of novel therapeutic values for existing drugs, i.e., drug repositioning, offers the great prospect for faster and low-risk drug development.
Yongcui Wang +3 more
doaj +1 more source
Molecular genetic studies of complex phenotypes [PDF]
Translational Research, 2012 The approach to molecular genetic studies of complex phenotypes evolved considerably during the recent years. The candidate gene approach, which is restricted to an analysis of a few single-nucleotide polymorphisms (SNPs) in a modest number of cases and controls, has been supplanted by the unbiased approach of genome-wide association studies (GWAS ...
openaire +2 more sources
Molecular phenotypes of ductal carcinoma-in-situ and invasive ductal carcinoma: A comparative study
Indian Journal of Pathology and Microbiology, 2012 Aims and Objectives: This study was aimed at analyzing the prevalence of molecular phenotypes in invasive ductal carcinoma (IDC) and coexisting ductal carcinoma-in-situ (DCIS) and to correlate with clinicopathological features.
Shilpa Gupta +4 more
doaj +1 more source
Severe hepatopathy and neurological deterioration after start of valproate treatment in a 6-year-old child with mitochondrial tryptophanyl-tRNA synthetase deficiency [PDF]
, 2018 Background: The first subjects with deficiency of mitochondrial tryptophanyl-tRNA synthetase (WARS2) were reported in 2017. Their clinical characteristics can be subdivided into three phenotypes (neonatal phenotype, severe infantile onset phenotype ...
De Bruyne, Ruth +9 more
core +1 more source
iScience, 2019 Summary: Neuroprotection is essential for the maintenance of normal physiological functions in the nervous system. This is especially true under stress conditions.
Pengfei Guo +11 more
doaj +1 more source
Analysis of the human diseasome reveals phenotype modules across common, genetic, and infectious diseases [PDF]
, 2014 Phenotypes are the observable characteristics of an organism arising from its response to the environment. Phenotypes associated with engineered and natural genetic variation are widely recorded using phenotype ontologies in model organisms, as are signs
Gkoutos, Georgios V +2 more
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Onset of human preterm and term birth is related to unique inflammatory transcriptome profiles at the maternal fetal interface. [PDF]
, 2017 BackgroundPreterm birth is a main determinant of neonatal mortality and morbidity and a major contributor to the overall mortality and burden of disease.
Andrews, William +13 more
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Analysis of phenotype array data from Biolog MicroPlates™
浙江大学学报. 农业与生命科学版, 2004 Biolog MicroPlates™ are employed to characterize Trichoderma isolates based on differential assimilation of test substrates and redox reactions in a 96-well test plate.
John Bissett, Carol Ann Nolan
doaj +1 more source
Pvr expression regulators in equilibrium signal control and maintenance of Drosophila blood progenitors. [PDF]
, 2014 Blood progenitors within the lymph gland, a larval organ that supports hematopoiesis in Drosophila melanogaster, are maintained by integrating signals emanating from niche-like cells and those from differentiating blood cells.
Banerjee, Utpal +3 more
core +1 more source