Results 111 to 120 of about 194,490 (314)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Phylogeny, diet, and cranial integration in australodelphian marsupials.

, 2007
Studies of morphological integration provide valuable information on the correlated evolution of traits and its relationship to long-term patterns of morphological evolution.
Goswami, A, Goswami Anjali, Anjali Goswami, Goswami, A.   +3 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The Ascomycota tree of life: a phylum-wide phylogeny clarifies the origin and evolution of fundamental reproductive and ecological traits

, 2009
We present a 6-gene, 420-species maximum-likelihood phylogeny of Ascomycota, the largest phylum of Fungi. This analysis is the most taxonomically complete to date with species sampled from all 15 currently circumscribed classes.
Untereiner, W., Cole, M.S., Miadlikowska, J., Ertz, D., Rogers, J., Mostert, L., Diederich, P., Groenewald, J.Z., Kauff, F., Fraker, E., Kohlmeyer, J., Ciufetti, L.M., Blackwell, M., Peterson, K., Yahr, R., Dyer, P.S., Lutzoni, F., Wang, Z., Castlebury, L.A., Rossman, A.Y., Trappe, J.M., Townsend, J.P., Sung, G.H., Sipman, H., Gueidan, C., Johnston, P.R., Brandon Matheny, P., Hodkinson, B.P., Volkmann-Kohlmeyer, B., Hillis, D.M., Rogers, J.D., Pfister, D.H., Hosaka, K., Shoemaker, R.A., Wingfield, M.J., Hansen, K., Geiser, D.M., Untereiner, W.A., Rauhut, A., Aptroot, A., Wynns, A., Inderbitzin, P., Sugiyama, J., Suh, S.-O., Hoog, G.S., de, Hofstetter, V., de Hoog, G.S., Summerbell, R.C., Trippe, K., Spatafora, J.W., López-Giráldez, F., Schoch, C.L., Arzanlou, M., Hewitt, D., Griffith, G.W., Crous, P.W., Lumbsch, H.T., Büdel, B., Gryzenhout, M., Andrie, R.M., Lücking, R., Bonito, G., Suh, S.O., Matheny, P.B., Crittenden, P.D., Zuccaro, A., Stenroos, S., Robbertse, B., O'Donnell, K., Sung, G.-H.   +69 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Chromosome Evolution in New World Monkeys (Platyrrhini) [PDF]

, 2012
During the last decades, New World monkey (NWM, Platyrrhini, Anthropoideae) comparative cytogenetics has shed light on many fundamental aspects of genome organisation and evolution in this fascinating, but also highly endangered group of neotropical ...
Müller, Stefan, Neusser, Michaela, de Oliveira, E. H. C.   +2 more
core   +1 more source

Leveraging phytochemicals: the plant phylogeny predicts sources of novel antibacterial compounds

Future Science OA, 2019
Aim: The goal of this study was to use phylogenetic evidence to determine plant families with high representation of antibacterial activity and identify potential sources to focus on for antibacterial drug discovery. Materials & methods: We reconstructed
Malini A Prasad, Christine P Zolnik, Jeanmaire Molina   +2 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Taxonomic revision, molecular phylogeny and zoogeography of the huntsman spider genus Eusparassus (Araneae: Sparassidae)

, 2013
The spider genus Eusparassus Simon, 1903 (Araneae: Sparassidae: Eusparassinae; stone huntsman spider) is revised worldwide to include 30 valid species distributed exclusively in Africa and Eurasia. The type species E.
Moradmand, Majid
core  

The first molecular phylogeny of Buthidae (Scorpiones) [PDF]

, 2003
The first partial phylogeny of family Buthidae (17 genera) is presented, based on molecular data (16S rRNA mitochondrial DNA). The strong support for a monophyletic Old World group of 13 genera (mainly Palearctic desert forms) is demonstrated, while ...
Gantenbein, Benjamin, Gromov, Alexander V., Fet, Victor, Lourenço, Wilson R., Lowe, Graeme   +4 more
core   +1 more source