Results 201 to 210 of about 1,842,096 (265)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
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The Molecular Interaction Process
Journal of Pharmaceutical Sciences, 2020Noncovalent molecular interactions, which are central to life, are thermodynamic processes that follow common interaction pathways. This commentary provides a foundation for both considering noncovalent interactions and the interplay between the protein properties and the solvent properties in determining the energetics.
Laue, Thomas M., Shire, Steven J.
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Molecular chaperones and the aging process
Biogerontology, 2000Molecular chaperones are abundant, well-conserved proteins responsible for the maintenance of the conformational homeostasis of cellular proteins and RNAs. Environmental stress is a proteotoxic insult to the cell, which leads to chaperone (heat shock protein, stress protein) induction. The protective role of chaperones is a key factor for cell survival
C, Sóti, P, Csermely
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Molecular processes and radiosensitivity
Strahlentherapie und Onkologie, 1997DNA double-strand breaks (DSB) are the most genotoxic lesions induced by ionizing radiation. At least 2 different pathways for DSB repair have been identified, homologous and non-homologous recombination.Studies on X-ray-sensitive mutants have led to the identification of several genes involved in processing of DSB in bacteria, yeast and mammalian ...
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Laser Control of Molecular Processes
Annual Review of Physical Chemistry, 1992The last 20 years have seen enormous strides in our understanding of the detailed dynamics of elementary chemical reactions ( 1 -3). With this understanding well in hand, attention has turned to controlling, rather than passively observing, molecular collision processes.
P, Brumer, M, Shapiro
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