Results 131 to 140 of about 5,633,983 (314)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Polarized Vesicles in Molecular Recognition and Catalysis
, 2004 This account summarizes studies on chemistry in polarized vesicles with rigid-rod molecules. Examples for the recognition of and self-assembly, molecular recognition, and catalysis in polarized vesicles are discussed with emphasis on remote control by ...
Stefan Matile +3 more
core +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Recognition of Patterned Molecular Ink with Phage Displayed Peptides
, 2016 Recognition of Patterned Molecular Ink with Phage Displayed ...
Yue Cui (212753) +4 more
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Asymmetric cyanoesterification of vinylarenes by electrochemical copper catalysis
Nature CommunicationsThe heterodifunctionalization of alkenes is an efficient and straightforward method for the preparation of highly functionalized molecules. However, enantioselective introduction of two different carbon-based functional groups in a single step using ...
Kehan Zhou, Niankai Fu
doaj +1 more source
Functionalized Congeners of 2H-Chromene P2Y6 Receptor Antagonists
CellsThe P2Y6 receptor (P2Y6R), a Gq-coupled receptor, is a potential drug discovery target for various inflammatory and degenerative conditions. Antagonists have been shown to attenuate colitis, acute lung injury, etc.
Paola Oliva +6 more
doaj +1 more source
Narratives on Career Development: A Reading Guide for Supervisors
These guidelines support the integration of professional career narratives within the EUR Development cycle for academic staff. They are designed to assist academic staff who hold supervisory roles. The guidelines can be used before or during Development
Recognition & Rewards
core +1 more source