Results 181 to 190 of about 1,422,910 (361)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Molecular mechanism of agonist recognition by the ligand‐binding core of the ionotropic glutamate receptor 4 [PDF]

, 2008
Christina Kasper, Karla Frydenvang, Peter Naur, Michael Gajhede, Darryl S. Pickering, J.S. Kastrup   +5 more
openalex   +1 more source

The 2′-deoxyribofuranoside of 3-phenyltetrahydropyrimido[4,5-c]pyridazin-7-one: a bicyclic nucleoside with sugar residues in N and S conformations, and its molecular recognition [PDF]

, 2022
Hui Mei, Simone Budow‐Busse, Dasharath Kondhare, H. Eickmeier, Hans Reuter, Frank Seela   +5 more
openalex   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Tuning Molecular Recognition of RNA and DNA via Sugar Modification

, 2005
Christian J. Leumann
openalex   +2 more sources

Molecular recognition of neutral molecules by rigid binaphthyl metalloclefts: Synthesis, complexation and calculations [PDF]

, 1992
Arie R. Van Doorn, David J. Rushton, Willem Verboom, David N. Reinhoudt, M. G. Bos   +4 more
openalex   +1 more source

Molecularly imprinted nanoparticles with recognition properties towards diphtheria toxin for ELISA applications [PDF]

, 2022
Süleyman Serdar Alkanlı, Fulya Dal, Merve Yaşar, Celal Güven, Memet Vezi̇r Kahraman, Nilhan Kayaman‐Apohan, Zerrin Aktaş, Oral Öncül, Ayhan Ünlü, Handan Akçakaya   +9 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Recognition of the Gastric Molecular Image Based on Decision Tree and Discriminant Analysis Classifiers by using Discrete Fourier Transform and Features

, 2018
Sevcan Aytaç Korkmaz
openalex   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source