Results 251 to 260 of about 1,422,910 (361)

Molecular Recognition of Amino Sugars by a Porphyrin-based Receptor in Aqueous Media

, 2010
Jung-Deog Lee, Dong-Hak Jang, Jong‐In Hong   +2 more
openalex   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Molecular recognition of natural compounds by MR1 and their implication in MAIT cell activation elucidated through McMD-based dynamic docking simulations. [PDF]

Sci Rep
Bekker GJ, Araki M, Oshima K, Okuno Y, Kamiya N.   +4 more
europepmc   +1 more source

Revisionary Studies in 'Synostemon' (Phyllanthaceae, Phyllantheae): Morphological and molecular data corroborate generic recognition of 'Synostemon' and with increased species diversity

, 2015
Ian Telford, Jeremy J. Bruhl, Peter C. van Welzen   +2 more
openalex   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Crafting defects in two-dimensional organic platelets via seeded coassembly enables emergent molecular recognition. [PDF]

Nat Commun
Tai W, Sun L, Liu S, Hu Q, Yu L, Che Y, Gong Y, Zhao J.   +7 more
europepmc   +1 more source

Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8

, 2006
Yann Hargous, Guillaume M. Hautbergue, Aura Tintaru, Lenka Skříšovská, Alexander P. Golovanov, James Stévenin, Lu Lian, Stuart A. Wilson, Frédéric H.‐T. Allain   +8 more
openalex   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Harnessing Molecular Recognition for Small-Molecule-Mediated Reversible Photochemical Control Over mRNA Translation. [PDF]

Angew Chem Int Ed Engl
Parmar S, Tenney L, Liang X, Routzahn JT, Sibley CD, Schneekloth JS.   +5 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source