Results 111 to 120 of about 602,330 (313)
2-Amino-1-methyl-4-oxo-4,5-dihydro-1H-imidazol-3-ium 4-methylbenzenesulfonate
IUCrData, 2016 The title molecular salt, C4H8N3O+·C7H7O3S−, is composed of a 2-amino-1-methyl-4-oxo-4,5-dihydro-1H-imidazol-3-ium cation and a 4-methylbenzenesulfonate anion.
V. Thayanithi +2 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Piperazin-1-ium 4-aminobenzoate monohydrate
IUCrData, 2016 The asymmetric unit of the title hydrated salt, C4H11N2+·C7H6NO2−·H2O, contains a piperazin-1-ium cation, a 4-aminobenzoate anion and a water molecule. One NH group of the piperazine ring is protonated and this ring adopts a chair conformation. The anion
P. Sivakumar +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
2-Amino-1-methyl-4-oxo-4,5-dihydro-1H-imidazol-3-ium 3-carboxy-4-hydroxybenzenesulfonate monohydrate
IUCrData, 2017 The asymmetric unit of the title molecular salt, C4H7N3O+·C7H5O6S−·H2O, contains a 5-sulfosalicylate anion, a creatininium cation and a water molecule of crystallization.
A. Malarkodi +4 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
4-Methylanilinium trichloroacetate
IUCrData, 2017 The asymmetric unit of the title molecular salt, C7H10N+·C2Cl3O2−, consists of two cations and two anions. In the crystal, N—H...O hydrogen bonds link the components into [100] chains incorporating R23(10) loops and weak π–π stacking [centroid-to ...
S. Suresh +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Staphylococcus aureus: salt stress, cell wall deficiency, and Biofílm formation [PDF]
, 2008 Staphylococcus aureus (S. aureus) is a major cause of chronic infection and is of particular concern in the infection of implanted prostheses. Biofilm formation offers bacteria innate protection from antimicrobial agents and prevents the eradication of ...
Beckingsale, Thomas
core
Crystal structure of quinolinium 2-carboxy-6-nitrobenzoate monohydrate
Acta Crystallographica Section E: Crystallographic Communications, 2015 In the anion of the title hydrated molecular salt, C9H8N+·C8H4NO6−·H2O, the protonated carboxyl and nitro groups makes dihedral angles of 27.56 (5) and 6.86 (8)°, respectively, with the attached benzene ring, whereas the deprotonated carboxy group is ...
J. Mohana +4 more
doaj +1 more source