Results 111 to 120 of about 5,099,016 (263)
IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd +9 morewiley +1 more sourceKDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan +16 morewiley +1 more sourceWhy do sequence signatures predict enzyme mechanism? Homology versus Chemistry [PDF]
, 2015 We identify, firstly, InterPro sequence signatures representing evolutionary relatedness and, secondly, signatures identifying specific chemical machinery.De Ferrari, Luna; id_orcid, Beattie, Kirsten E, De Ferrari, Luna, Mitchell, John B O, Beattie, Kirsten, Mitchell, John B. O. +5 morecore +1 more sourceMulti-Platform Next-Generation Sequencing of the Domestic Turkey (Meleagris gallopavo): Genome Assembly and Analysis [PDF]
, 2010 A synergistic combination of two next-generation sequencing platforms with a detailed comparative BAC physical contig map provided a cost-effective assembly of the genome sequence of the domestic turkey (Meleagris gallopavo).Kent M Reed, Zhang, Liqing, Zhang Hong-Bin, Kim, Heebal, Rami A Dalloul, Langenberger, D., Scheuring, C., Evans, Clive, Crooijmans, R. P. M. A., Lee, Mi-Kyung, Lee, Taeheon, Kim, H., Evans, C., Nefedov Mikhail, Mane, Shrinivasrao, Frederickson, K. M., Crooijmans, Richard P. M. A., Williams, K. P., Marz, M., Liqing Zhang, Paul Flicek, Dodgson, J. B., David Langenberger, Smith Jacqueline, Dodgson, J. B., Flicek, Paul, Dong, J. J., Jiang, A., Kim, K. W., Zhang Yang, Kim, H., Manja Marz, Long, J. A., Williams, Kelly P., Schatz Michael C., Julie A. Long, Raineri Emanuele, Folkerts, O., Otto Folkerts, Zhang, H.-B., McElroy, A. P., Zhang, L., Delany, Mary E., Long, Julie A., Kelly P. Williams, McElroy Audrey P., Paton, I. R., Beal Kathryn, de Jong, P., Vilella, A. J., Yorke, J. A., Vilella Albert J., Salzberg, Steven L., Harkins Tim T., Megens, H.-J., Kim Sungwon, Crasta Oswald, Burt, David W., Bouffard Pascal, Schroeder, S., Albert J. Vilella, Burt, D. W., Liliana Florea, Mane Shrinivasrao, Carl J. Schmidt, Modise, Thero, Harkins, T. T., Jacqueline Smith, Frederickson, Karin M., Kristal Cooper, Stadler Peter F., Martien A. M. Groenen, Steven L. Salzberg, van Tassell, C. P., Smith, E. J., Blomberg, L. A., Modise, T., Tafer, Hakim, Schmidt, C. J., William S Payne, Dong, Jennifer J., Florea Liliana, Vilella, A. J., Notredame, C., Lee, M. K., Smith, J., Kathryn Beal, Jiang, A., Bouffard, Pascal, Geo Pertea, Mi-Kyung Lee, Mane, S., Roberts, Richard J., Delany, M. E., Jerry B. Dodgson, Schmidt, Carl J., Pertea, Geo, Searle Stephen M. J., Williams, K. P., Frederickson Karin M., Beal, K., Tim T Harkins, Lee, T., Langenberger, David, Searle, S. M. J., Ruffier, M., Puiu, D., Dalloul, R. A., Van Tassell, C. P., Schatz, M. C., Julie A Long, Jennifer J Dong, Raineri, E., Modise Thero, Long Julie A., Reed, Kent M., De, Supriyo, Oswald Crasta, Zimin, Aleksey V., Folkerts, O., Zhang, Y., Schroeder Steven, Roger A Coulombe, Hoffmann Steve, Crasta, Oswald, McElroy, Audrey P., Tu, Zhijian Jake, Florea, L., Magali Ruffier, de, J. P., Curtis P. Van Tassell, Williams Kelly P., William S. Payne, Megens, H. J., Zhang, X., Bouffard, P., James A Yorke, Kaiser, Pete, Daniela Puiu, Stephen M. J. Searle, Modise, T., Notredame Cédric, Groenen, M. A. M., Hoffmann, Steve, Notredame, C��dric, Ruffier Magali, Taeheon Lee, Guillaume Marcais, Evans Clive, Le Ann Blomberg, Qioa, Dan, Herrero Javier, Zhang Liqing, Crooijmans, R. P., Kim, S., Evans, C., Prickett, Dennis, Groenen, M. A., Cooper, K., Tu, Z. J., Dalloul, R.A., De Supriyo, Kaiser, P., Schmidt, C. J., Van Tassell Curtis P., Tafer, H., Megens, Hendrik-Jan, Mane, Shrinivasrao P., Tafer, H., Marcais, G., Xiaojun Zhang, Crasta, O., Kyu-Won Kim, Dodgson Jerry B., Aleksey V. Zimin, Reed, K. M., Steve Hoffmann, Tu, Zhijian (Jake), Dalloul, Rami A., Ann Blomberg Le, Hoffmann, S., Zhang, Yang, David W Burt, Kent M. Reed, Pieter de Jong, Aslam, Luqman, Marz, M., Groenen, Martien A. M., Michael C Schatz, Zhijian Jake Tu, Burt David W., Pascal Bouffard, Pertea Geo, Richard P M A Crooijmans, Audrey P. McElroy, David W. Burt, Sonstegard, T. S., Marcais, G., Hakim Tafer, Smith, J., Zhang, H. B., Ruffier, Magali, Mikhail Nefedov, Albert J Vilella, Megens Hendrik-Jan, Clive Evans, Hendrik-Jan Megens, Kaiser Pete, Dennis Prickett, Puiu Daniela, Dan Qioa, Schroeder, S., Zhang, Hong-Bin, Zhang, Xiaojun, Audrey P McElroy, Zimin Aleksey V., Vilella, Albert J., Groenen, M. A. M., Martien A M Groenen, Coulombe, R. A., Supriyo De, Scheuring, C., Qioa, D., Van, T. C. P., Nefedov, M., Kim, K.-W., de Jong Pieter, McElroy, A. P., Folkerts, Otto, Yorke James A., Harkins, Tim T., Rami A. Dalloul, Zhijian (Jake) Tu, Lee Taeheon, Crooijmans, R.P.M.A., Searle, S. M., Megens, H. J., Edward J. Smith, Paton Ian R., Salzberg, S. L., Aleksey V Zimin, Cooper Kristal, Ian R. Paton, Emanuele Raineri, Langenberger David, Tu Zhijian (Jake), Long, J. A., Qioa, D., Coulombe, R. A., Pete Kaiser, Aslam Luqman, Mane, S., Delany, M. E., Schatz, M. C., Sonstegard Tad S., Marz, Manja, Payne, William S., Carl J Schmidt, Andrew Jiang, Tu, Z., James A. Yorke, Long, J.A., Kelly P Williams, Lee, T., Edward J Smith, Notredame, Cédric, Stadler, P. F., Aslam, L., Prickett Dennis, Zimin, A. V., Herrero, J., Searle, S. M. J., Burt, D. W., Luqman Aslam, Crasta, O., Langenberger, D., Kaiser, P., Stadler, P. F., Van Tassell, Curtis P., Schmidt Carl J., Sonstegard, Tad S., Marz Manja, Lee, M. K., Puiu, Daniela, Marcais Guillaume, Crooijmans Richard P. M. A., Blomberg, Le Ann, Groenen Martien A. M., de Jong, P., Ruffier, M., Tad S. Sonstegard, Dalloul, R. A., Jiang Andrew, Frederickson, K. M., Florea, Liliana, Aslam, M.L., Smith Edward J., de Jong, Pieter, Cédric Notredame, Kim, K. W., Searle, Stephen M. J., Smith, Jacqueline, Harkins, T. T., Smith, Edward J., Karin M Frederickson, Chantel Scheuring, Marcais, Guillaume, Dalloul Rami A., Curtis P Van Tassell, Kim, Kyu-Won, Kim, S., Mary E Delany, Hong-Bin Zhang, Michael C. Schatz, Scheuring, Chantel, Kim Kyu-Won, Jiang, Andrew, Payne, W. S., Folkerts Otto, Zhang, H. B., Zimin, A. V., Schroeder, Steven, Yorke, J. A., Megens, H.J.W.C., Heebal Kim, Payne, W. S., Ann Blomberg, Le, Beal, K., Smith, Jacqueline; id_orcid, Puiu, D., Reed, K. M., Crooijmans, R. P. M. A., Qioa Dan, Notredame, C., Pertea, G., Stephen M J Searle, Zhang Xiaojun, Prickett, D., Flicek, P., Salzberg, S. L., Karin M. Frederickson, Florea, L., Coulombe, Roger A., Smith, E. J., Delany Mary E., Scheuring Chantel, Sungwon Kim, Salzberg Steven L., Aslam, L., Jerry B Dodgson, Yang Zhang, Yorke, James A., Raineri, Emanuele, Paton, I. R., Bouffard, P., Tafer Hakim, Cooper, K., Dong, J. J., Nefedov, Mikhail, Kim Heebal, Cooper, Kristal, Roger A. Coulombe, Tim T. Harkins, Tad S Sonstegard, De, S., Nefedov, M., Herrero, Javier, Blomberg, L. A., Lee, M.-K., Mary E. Delany, Raineri, E., Zhang, L., Hoffmann, S., De, S., Peter F Stadler, Kim, Sungwon, Zhang, X., Thero Modise, Beal, Kathryn, Sonstegard, T. S., Richard P. M. A. Crooijmans, Prickett, D., Steven Schroeder, Payne William S., Jennifer J. Dong, Groenen, M., Ann Blomberg, L., Lee Mi-Kyung, Zhang, Y., Flicek, P., Zimin, A.V., Dong Jennifer J., Schatz, Michael C., Coulombe Roger A., Peter F. Stadler, Flicek Paul, Javier Herrero, Paton, Ian R., Herrero, J., Ian R Paton, Dodgson, Jerry B., Steven L Salzberg, Shrinivasrao Mane, Stadler, Peter F., Pertea, G., Reed Kent M. +405 morecore +1 more sourceDevelopmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley +13 morewiley +1 more source
