Results 151 to 160 of about 262,782 (224)

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

ERGA-BGE reference genome of <i>Xylophaga dorsalis -</i> a common deep-sea wood-boring bivalve with Atlantic-Mediterranean distribution. [PDF]

Open Res Eur
Taboada S, Gracia-Sancha C, Galià-Camps C, Böhne A, Monteiro R, Marcussen T, Oomen RA, Struck TH, Gut M, Aguilera L, Câmara Ferreira F, Cruz F, Gómez-Garrido J, Alioto TS, Martin F, Lazar A, Haggerty L, Bortoluzzi C.   +17 more
europepmc   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Draft Genome and Comparative Analysis of a <i>Cutaneotrichosporon jirovecii</i>-Related Yeast Recovered from a Human Fecal Sample. [PDF]

J Fungi (Basel)
Huang Y, Dai R, Liu F, Gou X, Zhu R, Yu S, Luo Z, Guo D, Sun T, Xiao M, Xu Y, Guo L.   +11 more
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Complete genome dataset of <i>Flavobacterium</i> sp. strain PL002 isolated from Antarctic <i>Porphyra</i> algae. [PDF]

Data Brief
Charles Labo J, Lavin P, Fan HY, Abu Bakar MF, Yusof NA.   +4 more
europepmc   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Haplotype-resolved genome of 'Pinot Noir' reveals DNA polymorphisms and allele-specific expression shaping terroir adaptation. [PDF]

Mol Hortic
Shangguan L, Ren Y, Xuan X, Li S, Pei D, Chen X, Zhang R, Mou D, Wang X, Chen W, Xu M, Leng X, Guan L, Chen J, Wang S, Fan H, Salman HM, Fang J.   +17 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source