Results 141 to 150 of about 30,277,677 (301)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Results of analysis of molecular variance for Ephedra przewalskii based on chloroplast DNA sequence data.

, 2016
Results of analysis of molecular variance for Ephedra przewalskii based on chloroplast DNA sequence data.
Ming-Li Zhang (402509), Zhi-Hao Su (3162276)   +1 more
core   +1 more source

AET5: A transcriptome-guided molecular generation framework with contrastive self-supervised learning.

PLoS Computational Biology
Gene expression profiles capture system-level drug responses and offer a promising basis for de novo molecular generation. However, their application is limited by data sparsity and experimental noise, which hinder the reliable mapping between disease ...
Zhikang Yuan, Xin Zhang, Gaoming Lin, Quan Zou, Subhashisa Swain, Yijie Ding, Prayag Tiwari, Shuofeng Yuan, Xiaoyi Guo   +8 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Global Update on Measles Molecular Epidemiology

Vaccines
Molecular surveillance of circulating measles variants serves as a line of evidence for the absence of endemic circulation and provides a means to track chains of transmission.
Bettina Bankamp, Gimin Kim, Derek Hart, Andrew Beck, Myriam Ben Mamou, Ana Penedos, Yan Zhang, Roger Evans, Paul A. Rota   +8 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

SRM Meitinger et al. Sequence Matters Data

The data set is the data set for the following article:Meitinger, K., Braun, M., & Behr, D. (2018). Sequence Matters in Web Probing: the Impact of the Order of Probes on Response Quality, Motivation of Respondents, and Answer Content.
Behr, Doroth\ue9e, GESIS - Leibniz-Institut f\ufcr Sozialwissenschaften, Meitinger, Katharina, GESIS - Leibniz-Institut f\ufcr Sozialwissenschaften, Braun, Michael, GESIS - Leibniz-Institut f\ufcr Sozialwissenschaften   +2 more
core   +1 more source

Sequence-Selective Receptors of Peptides. A Simple Molecular Design for Construction of Large Combinatorial Libraries of Receptors

, 2016
Sequence-Selective Receptors of Peptides.
Yuefei Shao (3038073), W. Clark Still (2994777)   +1 more
core   +1 more source