Results 121 to 130 of about 28,841,045 (284)

Low Diversity Cryptococcus neoformans Variety grubii Multilocus Sequence Types from Thailand Are Consistent with an Ancestral African Origin [PDF]

, 2011
The global burden of HIV-associated cryptococcal meningitis is estimated at nearly one million cases per year, causing up to a third of all AIDS-related deaths.
Fisher, M.D., Annemarie E. Brouwer, Thomas S Harrison, Simwami, SP, Matthew C Fisher, Boekhout, T, Khayhan Kantarawee, Aanensen, D.M., Brouwer Annemarie E., Hagen, F, Daniel A Henk, Matthew C. Fisher, Harrison, T.S., Henk Daniel A., Donnelly Christl A., Harrison Thomas S., Fisher Matthew C., Khayhan, K., David M. Aanensen, Aanensen David M., Annemarie E Brouwer, Brouwer, A.E., Donnelly, C.A., Aanensen, DM, Christl A Donnelly, Henk, DA, Brouwer, AE, Hagen, F., Henk, D.A., Sitali P. Simwami, Sitali P Simwami, Khayhan, K, Donnelly, CA, Ferry Hagen, Daniel A. Henk, Fisher, MC, Christl A. Donnelly, Teun Boekhout, Hagen Ferry, Kantarawee Khayhan, Simwami Sitali P., Boekhout, T., Boekhout Teun, Harrison, TS, Thomas S. Harrison, Simwami, S.P., David M Aanensen   +46 more
core   +1 more source

Essays on the Binary Representations of the DNA Data

DNA
The advancement of modern genomics has led to the large-scale industrial production of molecular data and scientific outcomes. Simultaneously, conventional DNA character alignments (sequence alignments) are utilized for DNA-based phylogenetic analyses ...
Evgeny V. Mavrodiev, Nicholas E. Mavrodiev   +1 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Research-tool patents: issues for health in the developing world

Bulletin of the World Health Organization, 2002
The patent system is now reaching into the tools of medical research, including gene sequences themselves. Many of the new patents can potentially preempt large areas of medical research and lay down legal barriers to the development of a broad category ...
Barton John H.
doaj  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Draft genome sequence of Colletotrichum acutatum sensu lato (Colletotrichum fioriniae) [PDF]

, 2014
In addition to its economic impact, Colletotrichum acutatum sensu lato is an interesting model for molecular investigations due to the diversity of host-determined specialization and reproductive lifestyles within the species complex.
Holub, Eric, Sreenivasaprasad, Prasad, Sukno, Serenella A., Sreenivasaprasad, S., Thon, M. R., Holub, E. B., Sukno, S. A., Baroncelli, Riccardo, Thon, Michael R.   +8 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Data Mining for Simple Sequence Repeats in Oil Palm Expressed Sequence Tags [PDF]

, 2009
Expressed Sequence Tags or ESTs are small pieces of DNA sequence that are generated by sequencing either one or both ends of an expressed gene. ESTs provide researchers with a quick and inexpensive route for discovering new genes, for obtaining data on ...
Vadivel Arunachalam, Aikkal Riju
core  

Exploring Protein Sequence Space Using Computationally Directed Recombination [PDF]

, 2006
Evolution has provided us with many protein sequences. However, these sequences represent a very small fraction of the possible sequences. In the laboratory, scientists have explored areas of sequence space not represented by natural proteins both to ...
Meyer, Michelle Margaret
core   +1 more source

Molecular characterisation of Newcastle disease virus isolates from different geographical regions in Mozambique in 2005

Onderstepoort Journal of Veterinary Research, 2012
Newcastle disease (ND) is regarded as a highly contagious and economically important disease in poultry and has a worldwide distribution. Viral determinants for Newcastle disease virus (NDV) virulence are not completely understood and viruses of ...
Raul Fringe, Anna-Mari Bosman, Karen Ebersohn, Shahn Bisschop, Celia Abolnik, Estelle Venter   +5 more
doaj