Results 111 to 120 of about 28,841,045 (284)

Integrated multiple sequence alignment [PDF]

, 2005
Sammeth M. Integrated multiple sequence alignment. Bielefeld (Germany): Bielefeld University; 2005.The thesis presents enhancements for automated and manual multiple sequence alignment: existing alignment algorithms are made more easily accessible and ...
Sammeth, Michael
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Probabilistic arithmetic automata : applications of a stochastic computational framework in biological sequence analysis [PDF]

, 2009
Herms I. Probabilistic arithmetic automata : applications of a stochastic computational framework in biological sequence analysis. Bielefeld (Germany): Bielefeld University; 2009.The immense amount of biological sequence data available these days ...
Herms, Inke
core  

Variable number of tandem repeat markers in the genome sequence of Mycosphaerella fijiensis, the causal agent of black leaf streak disease of banana (Musa spp) [PDF]

, 2010
. We searched the genome of Mycosphaerella fijiensis for molecular markers that would allow population genetics analysis of this plant pathogen. M. fijiensis, the causal agent of banana leaf streak disease, also known as black Sigatoka, is the most ...
Te Lintel Hekkert, B., S.B. Goodwin, Zapater, Marie-Françoise, Goodwin,, Stephen B., Lee, T.A.J., van der, M. Guzm�n, S.A.L. Garcia, Kema, G.H.J., Ferreira, C.F., Van der Lee, Theo A.J., C.F. Ferreira, Zapater, M.F., Ferreira, Claudia Fortes, M.-F. Zapater, T.A.J. Van der Lee, Souza, M.T., Kema, Gert H.J., Garcia, S.A.L., B. Te Lintel Hekkert, Guzmán, M., M.T. Souza Jr., Goodwin, S.B., Goodwin, Stephen B., G.H.J. Kema, Lintel Hekkert, B., te, van der Lee, T.A.J.   +25 more
core   +1 more source

A combined molecular typing approach does not discriminate Legionella pneumophila serogroup 1 strains of a predominant sequence-based type in Palermo, Italy

Journal of Infection and Public Health, 2009
Summary: The sequence-based type 1,4,3,1,1,1 of Legionella pneumophila sg.1 is predominant in the Palermo city environment since several years. In this study, extended sequence-based typing and pulsed field gel electrophoresis were used in a combined ...
Celestino Bonura, Caterina Mammina, Antonietta Vella, Santina Belfiore, Alfredo Chiarini, Anna Giammanco   +5 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Genetic Relationships among Reptilian and Mammalian Campylobacter fetus Strains Determined by Multilocus Sequence Typing [PDF]

, 2010
Reptile Campylobacter fetus isolates and closely related strains causing human disease were characterized by multilocus sequence typing. They shared similar to 90% nucleotide sequence identity with classical mammalian C.
Pruckler, J., Dep Infectieziekten Immunologie, Fitzgerald, C., van Bergen, M.A.P., Marcel A. P. van Bergen, Bergen, M.A.P., van, Robert J. Owen, Tu, Z.C., Kate E. Dingle, Janet Pruckler, Blaser, M.J., van Bergen, M.A., Strategic Infection Biology, Dingle, K.E., Zheng-Chao Tu, Collette Fitzgerald, Lawson, A.J., Wagenaar, J.A., Martin J. Blaser, Andrew J. Lawson, Jaap A. Wagenaar, Owen, R.J.   +21 more
core   +2 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

A BERT-based pretraining model for extracting molecular structural information from a SMILES sequence

Journal of Cheminformatics
Among the various molecular properties and their combinations, it is a costly process to obtain the desired molecular properties through theory or experiment.
Xiaofan Zheng, Yoichi Tomiura
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source