Results 101 to 110 of about 1,866,758 (264)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Probabilistic arithmetic automata : applications of a stochastic computational framework in biological sequence analysis

, 2009
Herms I. Probabilistic arithmetic automata : applications of a stochastic computational framework in biological sequence analysis. Bielefeld (Germany): Bielefeld University; 2009.The immense amount of biological sequence data available these days ...
Herms, Inke
core  

A Single Multilocus Sequence Typing (MLST) scheme for seven pathogenic Leptospira Species

, 2012
This study was funded by the Wellcome Trust. BGS and DMA were funded by Wellcome Trust grant 089472. SJP receives support from the NIHR Cambridge Biomedical Research CentreBackground: The available Leptospira multilocus sequence typing (MLST) scheme ...
Taylor, K, Cuicai Zhang (276536), Hoffmaster, Alex R., Chantratita, Narisara, Spratt, BG, Aanensen, David M., Amornchai, P., Lee D Smythe, Hoffmaster, AR, Galloway, R., Cuicai Zhang, Rudy A Hartskeerl, Alex R Hoffmaster, Feil, Edward J., Jiang, X, Taylor, K., Rudy A. Hartskeerl (94597), Day, N.P., Feil, E.J., Narisara Chantratita, Jiang, X., Holden, Matthew, Sharon J. Peacock (35782), Brian G. Spratt (10001), David M Aanensen, Chantratita, N., Thaipadungpanit, J, Boonsilp, S., Hartskeerl, Rudy A., Bailey, Mark S., Sharon J Peacock, Xiugao Jiang (276537), Amornchai, Premjit, Aanensen, D.M., Renee Galloway (276539), Narisara Chantratita (33898), Taylor, Kyle, Premjit Amornchai, Holden, MT, Koizumi, N., Bailey, MS, Mark S. Bailey (101757), Edward J Feil, Amornchai, P, Boonsilp, Siriphan, Nobuo Koizumi, Smythe, Lee D., Siriphan Boonsilp (276535), Lee D. Smythe (35773), Smythe, LD, Bailey, M.S., Day, Nicholas, Kyle Taylor (377049), Zhang, C, Jiang, Xiugao, Janjira Thaipadungpanit (35771), Day, Nicholas P., Siriphan Boonsilp, Galloway, R, Chantratita, N, Premjit Amornchai (247975), Holden, Matthew T. G., Edward J. Feil (35780), Peacock, Sharon J., Thaipadungpanit, J., Peacock, SJ, Wuthiekanun, V, Hartskeerl, RA, Vanaporn Wuthiekanun (35772), Craig, S., Galloway, Renee, Zhang, C., Holden, M.T.G., Craig, Scott, Scott Craig, Brian G Spratt, Hoffmaster, A.R., Holden, MTG, Feil, EJ, Matthew T G Holden, Boonsilp, S, Peacock, S.J., Matthew T. G. Holden (130258), Koizumi, N, Spratt, B.G., Renee Galloway, Wuthiekanun, V., Nicholas P. Day (160727), Koizumi, Nobuo, Nobuo Koizumi (276538), Aanensen, DM, Day, NP, David M. Aanensen (10000), Wuthiekanun, Vanaporn, Hartskeerl, R.A., Kyle Taylor, Spratt, Brian G., Janjira Thaipadungpanit, Vanaporn Wuthiekanun, Smythe, L.D., Nicholas P Day, Xiugao Jiang, Alex R. Hoffmaster (276540), Thaipadungpanit, Janjira, Mark S Bailey, Zhang, Cuicai, Scott Craig (276541), Craig, S   +107 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Sequence Studies for Text Data Augmentation and Molecular Generation [PDF]

Sequence Studies for Text Data Augmentation and Molecular Generation
Doctor of Philosophy in Informatics and Data ...
openaire   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Resolution among major placental mammal interordinal relationships with genome data imply that speciation influenced their earliest radiations

, 2010
Background: A number of the deeper divergences in the placental mammal tree are still inconclusively resolved despite extensive phylogenomic analyses.
Janke, Axel, Hallström, Björn M.
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source