Results 81 to 90 of about 1,866,758 (264)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Classification of hyper-variable Corynebacterium glutamicum surface-layer proteins by sequence analyses and atomic force microscopy

, 2004
Hansmeier N, Bartels FW, Ros R, et al. Classification of hyper-variable Corynebacterium glutamicum surface-layer proteins by sequence analyses and atomic force microscopy. J Biotechnol.
Hansmeier, Nicole, Ros, Robert, Bartels, Frank Wilco, Tauch, Andreas, Pühler, Alfred ; https://orcid.org/, Kalinowski, Jörn, Anselmetti, Dario ; https://orcid.org/   +6 more
core   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

A macro- and micro-evolutionary investigation of African Camponotus ants

, 2002
Bibliography: leaves 213-233.Camponotus than the cytochrome oxidase II gene, based on almost all measures of phylogenetic utility. The primary hypothesis proposed to account for this observation is that these two mitochondrial genes are evolving under ...
Eick, Brigitte N
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Species status of Neisseria gonorrhoeae: Evolutionary and epidemiological inferences from multilocus sequence typing

, 2007
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work
Julia S Bennett, Maiden, MCJ, Keith A Jolley, Ian M Feavers, Jolley Keith A, Martin CJ Maiden, Bennett, JS, Feavers, IM, Maiden Martin CJ, Maiden, MC, Hart C Anthony, Saunders, Nigel, Saunders, NJ, C Anthony Hart, P Frederick Sparling, Sparling, PF, Saunders Nigel J, Bennett Julia S, Nigel J Saunders, Hart, CA, Sparling P Frederick, Jolley, KA, Feavers Ian M   +22 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Multilocus sequence typing as a replacement for serotyping in Salmonella enterica [PDF]

, 2012
Salmonella enterica subspecies enterica is traditionally subdivided into serovars by serological and nutritional characteristics. We used Multilocus Sequence Typing (MLST) to assign 4,257 isolates from 554 serovars to 1092 sequence types (STs).
Uesbeck, Alexandra, Hales, James, Satheesh Nair, Wain John, Krauland, Mary G., Harbottle Heather, Mary G. Krauland (157219), Zhou, Z, Hale, JL, Brisse Sylvain, Brisse, S., Nair, S, Alexandra Uesbeck (157229), Zhou Zhemin, Brisse, Sylvain, Harbottle, Heather, John Wain (157211), Weill, FX, Zhou, Z., Weill, François-Xavier, Zhemin Zhou (157214), Heather Harbottle (157226), Vartul Sangal, The S.enterica MLST study group, Gordon Dougan, Hale James L., Hale, J.L., Sangal, V, Achtman, Mark, Sylvain Brisse, Zhou, Zhemin, Harrison, LH, Sangal, V., Nair, Satheesh, Zhemin Zhou, Nair, S., Wain, J., Harrison, Lee H., Uesbeck, A., Bessen, Debra E., Achtman, M., Harrison, L.H., François-Xavier Weill, Vartul Sangal (157216), Mark Achtman, Sylvain Brisse (87594), Dougan, G., Wain, John, Sangal, Vartul, Harbottle, H., Alexandra Uesbeck, Uesbeck Alexandra, Weill, F., Lee H. Harrison (157231), Hale, James L., Lee H Harrison, Heather Harbottle, Hale, James, Dougan Gordon, Krauland, M., Harrison, L., Wain, J, Mark Achtman (126786), James L. Hale (157222), Achtman Mark, Krauland, M.G., Nair Satheesh, François-Xavier Weill (157212), Weill François-Xavier, Harrison, Lee, Mary G Krauland, James L Hale, Dougan, Gordon, Brisse, S, Krauland, Mary, Hale, J., Sangal Vartul, S. Enterica MLST Study Group, Gordon Dougan (30395), Weill, F.X., Uesbeck, A, Satheesh Nair (157213), Krauland, MG, John Wain, Harbottle, H, Harrison Lee H., Krauland Mary G., Dougan, G, Achtman, M   +88 more
core   +1 more source