Results 61 to 70 of about 30,277,677 (301)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Variable number of tandem repeat markers in the genome sequence of Mycosphaerella fijiensis, the causal agent of black leaf streak disease of banana (Musa spp) [PDF]

, 2010
. We searched the genome of Mycosphaerella fijiensis for molecular markers that would allow population genetics analysis of this plant pathogen. M. fijiensis, the causal agent of banana leaf streak disease, also known as black Sigatoka, is the most ...
Te Lintel Hekkert, B., S.B. Goodwin, Zapater, Marie-Françoise, Goodwin,, Stephen B., Lee, T.A.J., van der, M. Guzm�n, S.A.L. Garcia, Kema, G.H.J., Ferreira, C.F., Van der Lee, Theo A.J., C.F. Ferreira, Zapater, M.F., Ferreira, Claudia Fortes, M.-F. Zapater, T.A.J. Van der Lee, Souza, M.T., Kema, Gert H.J., Garcia, S.A.L., B. Te Lintel Hekkert, Guzmán, M., M.T. Souza Jr., Goodwin, S.B., Goodwin, Stephen B., G.H.J. Kema, Lintel Hekkert, B., te   +24 more
core   +1 more source

Tan et al., LSP2 (Molecular Cell) Supplement

, 2022
Uncropped Gel images and expanded sequence alignments from Tan, et al., ("The human mitochondrial genome contains a second light strand promoter").Published in Molecular Cell.Lead contact: Claes M. Gustafsson (claes.gustafsson@medkem.gu.se)Data
Tan, B (via Mendeley Data), Tan, Benedict   +1 more
core   +1 more source

Natural variability of Kozak sequences correlates with function in a zebrafish model. [PDF]

PLoS ONE, 2014
In eukaryotes, targeting the small ribosomal subunit to the mRNA transcript requires a Kozak sequence at the translation initiation site. Despite the critical importance of the Kozak sequence to regulation of gene expression, there have been no ...
Steven J Grzegorski, Estelle F Chiari, Amy Robbins, Phillip E Kish, Alon Kahana   +4 more
doaj   +1 more source

Molecular Sequence Data of Hepatitis B Virus and Genetic Diversity After Vaccination [PDF]

American Journal of Epidemiology, 2009
The effect of vaccination programs on transmission of infectious disease is usually assessed by monitoring programs that rely on notifications of symptomatic illness. For monitoring of infectious diseases with a high proportion of asymptomatic cases or a low reporting rate, molecular sequence data combined with modern coalescent-based techniques offer ...
van Ballegooijen, WMrivm, van den Houdt, R, Bruisten, SM, Boot, HJrivm, Coutinho, RArivm, Wallinga, Jrivm   +5 more
openaire   +4 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

molecular-cell-D-19-00528-mendeley-data

, 2019
These are the original gel images for MOLECULAR-CELLD-19-00528 ...
Wan, B (via Mendeley Data), Bingbing Wan (6988883), Wan, Bingbing   +2 more
core   +1 more source

Reliability and Utility of Standard Gene Sequence Barcodes for the Identification and Differentiation of Cyst Nematodes of the Genus Heterodera

Journal of Nematology, 2022
Difficulties inherent in the morphological identification of cyst nematodes of the genus Heterodera Schmidt, 1871, an important lineage of plant parasites, has led to broad adoption of molecular methods for diagnosing and differentiating species.
Huston Daniel C., Khudhir Manda, Hodda Mike   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source