Results 51 to 60 of about 1,866,758 (264)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A molecular phylogeny of Hypnales (Bryophyta) inferred from ITS2 sequence-structure data [PDF]

BMC Research Notes, 2010
Hypnales comprise over 50% of all pleurocarpous mosses. They provide a young radiation complicating phylogenetic analyses. To resolve the hypnalean phylogeny, it is necessary to use a phylogenetic marker providing highly variable features to resolve species on the one hand and conserved features enabling a backbone analysis on the other.
Merget, Benjamin, Wolf, Matthias
openaire   +4 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Reconstructing mammalian phylogenies : a detailed comparison of the cytochrome b and cytochrome oxidase subunit I mitochondrial genes [PDF]

, 2010
The phylogeny and taxonomy of mammalian species were originally based upon shared or derived morphological characteristics. However, genetic analyses have more recently played an increasingly important role in confirming existing or establishing often ...
Adrian M. T. Linacre, Kitchener Andrew C., Tobe, S.S., Kitchener, Andrew C., Kitchener, Andrew, Linacre Adrian M. T., Andrew C. Kitchener, Linacre, A.M.T., Tobe Shanan S., Linacre, Adrian Matthew Thornton, Andrew C Kitchener, Kitchener, A.C., Tobe, Shanan, Shanan S. Tobe, Kitchener, Andrew C, Linacre, Adrian, Adrian M T Linacre, Shanan S Tobe, Tobe, Shanan S   +18 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Variable number of tandem repeat markers in the genome sequence of Mycosphaerella fijiensis, the causal agent of black leaf streak disease of banana (Musa spp) [PDF]

, 2010
. We searched the genome of Mycosphaerella fijiensis for molecular markers that would allow population genetics analysis of this plant pathogen. M. fijiensis, the causal agent of banana leaf streak disease, also known as black Sigatoka, is the most ...
Te Lintel Hekkert, B., S.B. Goodwin, Zapater, Marie-Françoise, Goodwin,, Stephen B., Lee, T.A.J., van der, M. Guzm�n, S.A.L. Garcia, Kema, G.H.J., Ferreira, C.F., Van der Lee, Theo A.J., C.F. Ferreira, Zapater, M.F., Ferreira, Claudia Fortes, M.-F. Zapater, T.A.J. Van der Lee, Souza, M.T., Kema, Gert H.J., Garcia, S.A.L., B. Te Lintel Hekkert, Guzmán, M., M.T. Souza Jr., Goodwin, S.B., Goodwin, Stephen B., G.H.J. Kema, Lintel Hekkert, B., te, van der Lee, T.A.J.   +25 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Genetic Relationships among Reptilian and Mammalian Campylobacter fetus Strains Determined by Multilocus Sequence Typing [PDF]

, 2010
Reptile Campylobacter fetus isolates and closely related strains causing human disease were characterized by multilocus sequence typing. They shared similar to 90% nucleotide sequence identity with classical mammalian C.
Pruckler, J., Dep Infectieziekten Immunologie, Fitzgerald, C., van Bergen, M.A.P., Marcel A. P. van Bergen, Bergen, M.A.P., van, Robert J. Owen, Tu, Z.C., Kate E. Dingle, Janet Pruckler, Blaser, M.J., van Bergen, M.A., Strategic Infection Biology, Dingle, K.E., Zheng-Chao Tu, Collette Fitzgerald, Lawson, A.J., Wagenaar, J.A., Martin J. Blaser, Andrew J. Lawson, Jaap A. Wagenaar, Owen, R.J.   +21 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source