Results 41 to 50 of about 1,866,758 (264)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Sequence alignment, mutual information, and dissimilarity measures for constructing phylogenies

, 2011
Background: Existing sequence alignment algorithms use heuristic scoring schemes based on biological expertise, which cannot be used as objective distance metrics.
Penner, Orion, Grassberger, Peter, Maya Paczuski, Paczuski Maya, Peter Grassberger, Orion Penner, Penner Orion, Grassberger Peter, Paczuski, Maya   +8 more
core   +1 more source

Louse (Insecta : Phthiraptera) mitochondrial 12S rRNA secondary structure is highly variable [PDF]

, 2002
Lice are ectoparasitic insects hosted by birds and mammals. Mitochondrial 12S rRNA sequences obtained from lice show considerable length variation and are very difficult to align.
Page, R.D.M., Cruickshank, R., Johnson, K.P.   +2 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Multilocus sequence typing (MLST) for lineage assignment and high resolution diversity studies in Trypanosoma cruzi. [PDF]

, 2011
BACKGROUND: Multilocus sequence typing (MLST) is a powerful and highly discriminatory method for analysing pathogen population structure and epidemiology. Trypanosoma cruzi, the protozoan agent of American trypanosomiasis (Chagas disease), has remarkable
Michael A. Miles, Acosta , N,, Llewellyn Martin S., Nidia Acosta, Louisa A Messenger, Acosta Nidia, Bhattacharyya Tapan, Carrasco, Hernan J, Yeo, Matthew, Hernan J Carrasco, Bhattacharyya , T,, Miles, Michael A., Llewellyn , MS,, Isabel L. Mauricio, Yeo Matthew, Miles, M.A., Michael D Lewis, Messenger, Louisa A, Yeo, M., Acosta, N., Mauricio, Isabel Larguinho, Matthew Yeo, Patricio Diosque, Llewellyn, Martin S, Martin S Llewellyn, Miles, Michael A, Lewis, M.D., Messenger Louisa A., Diosque, P., Lewis, Michael D, Miles , MA., Carrasco Hernan J., Llewellyn, Martin S., Llewellyn, M.S., Lewis Michael D., Messenger, L.A., Acosta, Nidia, Lewis, Michael D., Carrasco, H.J., Mauricio, I.L., Mauricio, Isabel L., Messenger, Loisa A., Lewis , MD,, Yeo , M,, Michael A Miles, Miles Michael A., Bhattacharyya, Tapan, Louisa A. Messenger, Carrasco , HJ,, Messenger , LA,, Isabel L Mauricio, Bhattacharyya, T., Diosque Patricio, Hernan J. Carrasco, Martin S. Llewellyn, Diosque, Patricio, Michael D. Lewis, Mauricio, Isabel L, Mauricio Isabel L., Diosque , P,, Tapan Bhattacharyya, Carrasco, Hernán J.   +61 more
core   +1 more source

Bootstrap confidence for molecular evolutionary estimates from tumor bulk sequencing data

Frontiers in Bioinformatics, 2023
Bulk sequencing is commonly used to characterize the genetic diversity of cancer cell populations in tumors and the evolutionary relationships of cancer clones. However, bulk sequencing produces aggregate information on nucleotide variants and their sample frequencies, necessitating computational methods to predict distinct clone sequences and their ...
Jared Huzar, Madelyn Shenoy, Maxwell D. Sanderford, Sudhir Kumar, Sudhir Kumar, Sudhir Kumar, Sayaka Miura, Sayaka Miura   +7 more
openaire   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Tidying up international nucleotide sequence databases [PDF]

, 2011
Sequence analysis of the ribosomal RNA operon, particularly the internal transcribed spacer (ITS) region, provides a powerful tool for identification of mycorrhizal fungi.
Schüssler, Arthur, Kohout, Petr, Jairus, Teele, Larsson, Karl-Henrik, Kõljalg, Urmas, Nilsson, R. Henrik, Grelet, Gwen-Aëlle, Ryberg, Martin, Veldre, Vilmar, Abarenkov, Kessy, Oja, Jane, Bonito, Gregory M., Tedersoo, Leho   +12 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source