Results 291 to 300 of about 4,241,168 (373)

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

MFE-ACVP: anti-coronavirus peptide prediction based on multimodal feature extraction and ensemble learning. [PDF]

Brief Bioinform
Kang L, Bao L, Zhang P, Yu X, Zhang L, Zhou W, Bai Y.   +6 more
europepmc   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Artificial intelligence in bioinformatics: a survey. [PDF]

Brief Bioinform
Jiang J, Li Y, Cao S, Shan Y, Liu Y, Fei T, Yu Y, Feng Y, Li Y, Li Y, Yuan J.   +10 more
europepmc   +1 more source

P-2334. Clesrovimab Binding Site Conservation on the RSV F Protein: An Evaluation of RSV Molecular Sequencing Data from 2019-2023 and GenBank Sequence Analysis

Arthur Fridman, Latisha Love‐Gregory, Radha Railkar, Diane Levitan, Julie Strizki, Kalpit A. Vora   +5 more
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Exploring the size limits of Bionano optical genome mapping to resolve alternative structures of linked interspersed chromosomal duplications. [PDF]

Genome Med
Pei Y, Calpena E, Brown JM, Schwessinger R, Platts L, McGowan SJ, Ashraf T, Forzano F, Hurst JA, Jones WD, Sarkar A, Gibbons RJ, Twigg SRF, Wilkie AOM.   +13 more
europepmc   +1 more source

A scalable equivariant graph network framework for precise protein function prediction. [PDF]

Genome Biol
Ran Z, Guo X, Pan T, Bi Y, Hao Y, Sun H, Song J, Li F.   +7 more
europepmc   +1 more source

Of sequences and images - diversity and quantity of Arctic epipelagic zooplankton by an integrative approach. [PDF]

J Plankton Res
Laakmann S, Cornils A, Metfies K, Koplin J, Neuhaus S, Bunse C, Niehoff B, Flores H.   +7 more
europepmc   +1 more source

CdmR, a MarR family protein from <i>Clostridioides difficile</i>, binds with positive cooperativity in the predicted promoter region of a MATE efflux transporter. [PDF]

Biochem Biophys Rep
Canepa J, Garcia-Ortiz R, Thompson K, Glidden J, Panchal B, Takahashi R, Kim DE, Wilkinson SP.   +7 more
europepmc   +1 more source