Results 111 to 120 of about 73,361 (307)

Study on the Synthesis Method of [11C]Methionine Using Molecular Sieve as Desiccant

open access: yesKorean Journal of Clinical Laboratory Science
[11C]Methionine is used widely for brain tumor diagnosis via positron emission tomography. Moisture generated during the synthesis of [11C]methionine reduces the synthesis yield. Therefore, a desiccant is used to remove moisture.
Young Si PARK   +6 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Study of Acetylsalicylic Acid Adsorption Using Molecular Sieves

open access: yesAdsorption Science & Technology, 2015
Molecular sieves can be used as a host matrix to encapsulate several drugs. Here, we studied the adsorption of acetylsalicylic acid (ASA) in HUS-Y, HZSM-5 and silicalite-1 zeolites, as well as in the mesoporous sieve Si-MCM-41, and compared their ...
G.A. Assumpção   +4 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

A computational study on the adsorption of the major ring-transformation products of methyloxirane in HY and HZSM-5 zeolites [PDF]

open access: yes, 2008
The adsorption of dioxolane and dioxane derivatives in HY and HZSM-5 zeolites was studied computationally. The molecules are the main ring-transformation products of methyloxirane over these zeolites. Experimental work showed that the cyclic dimerisation
Pálinkó, István, Szegvári, Gábor
core  

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

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