Results 91 to 100 of about 8,826,528 (283)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Solvation-Driven Ion Transport and Selectivity in Interfacial Separation Systems

Growing global demands for energy and clean water highlight the need for more advanced and efficient separation and synthesis technologies. Advancing a mechanistic understanding of how ion solvation governs transport and selectivity across chemically ...
Tye David Milazzo (23723232)
core   +1 more source

Comments on the Competitive Preferential Solvation Theory

, 1990
Article commenting on the competitive preferential solvation ...
Zvaigzne, Anita I., Tucker, Sheryl A. (Sheryl Ann), Acree, William E. (William Eugene)   +2 more
core   +1 more source

Determination of Effective Functional Monomer and Solvent for R(+)-Cathinone Imprinted Polymer Using Density Functional Theory and Molecular Dynamics Simulation Approaches

Indonesian Journal of Chemistry, 2017
Determination of effective functional monomer and solvent for R(+)-cathinone imprinted polymer through modeling has been done using density functional theory (DFT) and molecular dynamics (MD) simulation approaches.
Andrian Saputra, Karna Wijaya, Ria Armunanto, Lisa Tania, Iqmal Tahir   +4 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Electron transfer theory revisited: Quantum solvation effect

, 2006
The effect of solvation on ET rate processes has been investigated on the basis of the exact theory constructed in J. Phys. Chem. B 110:11438, 2006. The nature of solvation has been studied in close relation with the mechanism of ET processes.
Cui, Ping, Yan, Yijing, 严以京, He, Guczhong, Mo, Yan, Han, Ping, Xu, Rui-Xue   +6 more
core  

In silico characterization of Ciwujianoside E: Structural features, solvation dynamics, and eco-toxicological assessment

Computational and Structural Biotechnology Journal
This work presents an in-depth characterization of Ciwujianoside E through Density Functional Theory (DFT) and Quantum Theory of Atoms in Molecules (QTAIM) analyses.
A. Marta Navarro-Cuñado, María J. Tapia, Sergio de-la-Huerta-Sainz, Alberto Gutiérrez, Santiago Aparicio   +4 more
doaj   +1 more source

Interparticle potential of 10 nanometer titanium nanoparticles in liquid sodium: theoretical approach

Nuclear Engineering and Technology, 2015
A suspension of titanium nanoparticles (Ti NPs) in liquid sodium (Na) has been proposed as a method to mitigate the violent sodium–water reaction (SWR).
Soo Jae Kim, Gunyeop Park, Hyun Sun Park, Moo Hwan Kim, Jehyun Baek   +4 more
doaj   +1 more source