Results 131 to 140 of about 8,826,528 (283)

Comprehensive analysis of the electronic, thermodynamic, and spectroscopic properties of a Cu(II)-based complex with 1,10-phenanthroline and L-glutamine

Heliyon
This study reports additional information's of geometric, electronic, thermodynamic, and vibrational properties of a Cu(II) complex with 1,10-phenanthroline and L-glutamine ligands.
Marinaldo V. Souza Junior, João G. Oliveira Neto, Walajhone O. Pereira, Jéssica A.O. Rodrigues, Jailton R. Viana, Aramys S. Reis, Mateus R. Lage, Guilherme G.C. Carvalho, Cláudia O. Pessoa, Adenilson O. dos Santos, Francisco F. de Sousa   +10 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Minnesota Solvation Database (MNSOL) version 2012

, 2012
The Minnesota Solvation Database and User Manual is available for download as a .zip file named MNSolDatabase-v2012.The Minnesota Solvation Database consists of a collection of 3037 experimental free energies of solvation or transfer free energies for ...
Chambers, Candee C, Giesen, David J, Marenich, Aleksandr V, Kelly, Casey P, Cramer, Christopher J, Thompson, Jason D, Hawkins, Gregory D, Winget, Paul, Truhlar, Donald G   +8 more
core   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Predicting Site-Binding Modes of Ions and Water to Nucleic Acids Using Molecular Solvation Theory. [PDF]

J Am Chem Soc, 2019
Giambaşu GM, Case DA, York DM.
europepmc   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Computational evaluation of novel hydantoin hydrazone hybrids as potential antimicrobial candidates against DNA gyrase and CYP51

Scientific Reports
Hydantoin hydrazone hybrids, including compounds 2, 3a–d, 4a–b, 5a–b, and 6, were computationally investigated as potential dual-target antimicrobial candidates using an integrated workflow comprising density functional theory (DFT), molecular docking ...
Nada A. Khaled, Nagy M. Khalifa, Medhat A. Ibrahim, Neama A. Mohamed, Osama M. Ahmed, Sayed A. Ahmed   +5 more
doaj   +1 more source