Results 41 to 50 of about 8,826,528 (283)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Atomistic characterization of the active-site solvation dynamics of a model photocatalyst

Nature Communications, 2016
Interactions between reactive excited states of molecular photocatalysts and surrounding solvent can dictate reaction pathways, but are not readily accessible to conventional spectroscopic methods. Here the authors use diffuse X-ray scattering and theory
Tim B. van Driel, Kasper S. Kjær, Robert W. Hartsock, Asmus O. Dohn, Tobias Harlang, Matthieu Chollet, Morten Christensen, Wojciech Gawelda, Niels E. Henriksen, Jong Goo Kim, Kristoffer Haldrup, Kyung Hwan Kim, Hyotcherl Ihee, Jeongho Kim, Henrik Lemke, Zheng Sun, Villy Sundström, Wenkai Zhang, Diling Zhu, Klaus B. Møller, Martin M. Nielsen, Kelly J. Gaffney   +21 more
doaj   +1 more source

Safe and Stable Lithium Metal Batteries Enabled by an Amide-Based Electrolyte

Nano-Micro Letters, 2022
Highlights A novel amide-based nonflammable electrolyte is proposed. The formation mechanism and solvation chemistry are investigated by molecular dynamics simulations and density functional theory.
Wanbao Wu, Yiyang Bo, Deping Li, Yihong Liang, Jichuan Zhang, Miaomiao Cao, Ruitian Guo, Zhenye Zhu, Lijie Ci, Mingyu Li, Jiaheng Zhang   +10 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Theoretical Insights into the Molecular Interaction in Li-Ion Battery Electrolytes from the Perspective of the Dielectric Continuum Solvation Model

Crystals
Rational electrolyte design stands as a frontier in the research and development of Li-ion batteries. Nevertheless, detailed investigations about the influence of the dielectric continuum solvation model on molecular interactions are still limited ...
Yumeng Zhao, Runmin Li, Xiaoxiao Li, Xinsheng Zhao, Yunsong Li, Yuxiao Lin   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Computing the aqueous solubility of organic drug-like molecules and understanding hydrophobicity [PDF]

, 2015
This thesis covers a range of methodologies to provide an account of the current (2010-2014) state of the art and to develop new methods for solubility prediction.
McDonagh, James L.
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Ion solvation in aqueous-organic mixtures [PDF]

, 2004
The importance of ion solvation in determining the properties of electrolyte solutions in aqueous-organic solvent mixtures is discussed. Solubility measurements are shown to be particularly useful for determining the Gibbs energies of transfer of ions ...
Hefter, G.T., Hefter, G.
core  

Effects of molecular size in solvation dynamics

, 1990
The effects of molecular size on the dynamics of polar solvation are studied by using a microscopic theory which includes the translational relaxation modes of the solvent consistently.
Chandra, Amalendu, Bagchi, Biman
core   +1 more source