Results 251 to 260 of about 4,508,859 (303)

Research on the function of GPX4 in tumor-targeted treatment based on its molecular structure and features. [PDF]

Front Oncol
Geng H, Ma L, Wu L, Yao C, Wang C, Gan X, Li Y, Chen F.   +7 more
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

PairReg: A method for enhancing the learning of molecular structure representation in equivariant graph neural networks. [PDF]

PLoS One
Ren Z, Liu Y, Zhang S.
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Monothiooxalamide-Benzothiazole Hybrids: Predictive Docking on HDAC6, Synthesis, Molecular Structure, and Antiproliferative Activity on Breast Cancer Cells. [PDF]

Int J Mol Sci
Macías-Hernández CE, Balbuena-Rebolledo I, García-Báez EV, Cabrera-Pérez LC, Godínez-Victoria M, Rosales-Hernández MC, Padilla-Martínez II.   +6 more
europepmc   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

The Importance of Molecular Structure for Textural and Physicochemical Properties of Extruded Wheat Flour. [PDF]

Foods
Chai Y, Wang R, Zhang B, Tang Y, Li C, Guo B, Li M.   +6 more
europepmc   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Synthesis, photolumescence properties, solvent effect in molecular structure level, topology, and docking studies on Sulfa drug derivative. [PDF]

Sci Rep
Elangovan N, Al-Hussain SA, Kayarohanam S, Wong LS, Gomha SM, Djearamane S, Zaki MEA.   +6 more
europepmc   +1 more source