Results 261 to 270 of about 19,554,258 (410)

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Reversibly Charge-Switching Polyzwitterionic/Polycationic Coatings for Biomedical Applications: Optimizing the Molecular Structure for Improved Stability. [PDF]

Langmuir
Schneider SHE, Lehnert K, Thome MA, Kraegeloh A, Lienkamp K.   +4 more
europepmc   +1 more source

Molecular structure and functional activity of nerve cells: a symposium organized by the American Institute of Biological Sciences and sponsored by the Office of Naval Research; held in Washington, D.C., June 3-4, 1955

, 1956
R. G. Grenell, L. J. Mullins
openalex   +2 more sources

The Molecular Structure of Dimethyltrisulfide, (CH3)2S3 [PDF]

, 1948
Jerry Donohue, Verner Schomaker
openalex   +1 more source

Molecular Structure of the Human CFTR Ion Channel

Cell, 2017
Fangyu Liu, Zhe Zhang, László Csanády, D. Gadsby, Jue Chen   +4 more
semanticscholar   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

13C-Labelled Folates as NMR Probes of the Binding of Folate to Bacterial Dihydrofolate Reductases

Pteridines, 1991
Cheung H. T. A., Chau D. D., Morrison J. F., Birdsall B., Feeney J.   +4 more
doaj   +1 more source

Phylogenetic analysis and molecular structure of NS1 proteins of porcine parvovirus 5 isolates from Mexico. [PDF]

Arch Virol
Vargas-Ruiz A, Araiza-Hernández DM, González-Díaz FR, Marín-Flamand E, Sánchez Betancourt JI, Sánchez-Mendoza AE, García-Camacho LA.   +6 more
europepmc   +1 more source

Vibration Spectra and Molecular Structure VIII. Absorption Spectra of Light and Heavy Phenol and Aniline Vapors [PDF]

, 1939
Van Zandt Williams, R. Hofstadter, R. Herman   +2 more
openalex   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source