Results 41 to 50 of about 4,073,182 (253)

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko, Segev Gabay, Jonathan Roth, Amit Ringel, Rina Dvir, Shlomi Constantini   +5 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Respiratory Syncytial Virus: New Challenges for Molecular Epidemiology Surveillance and Vaccination Strategy in Patients with ILI/SARI

Vaccines, 2021
Several respiratory pathogens are responsible for influenza-like illness (ILI) and severe respiratory infections (SARI), among which human respiratory syncytial virus (hRSV) represents one of the most common aetiologies.
Fabio Tramuto, Carmelo Massimo Maida, Daniela Di Naro, Giulia Randazzo, Francesco Vitale, Vincenzo Restivo, Claudio Costantino, Emanuele Amodio, Alessandra Casuccio, Giorgio Graziano, Palmira Immordino, Walter Mazzucco   +11 more
doaj   +1 more source

Weekly Influenza Surveillance Report Week 20 2002 [PDF]

, 2002
This is the final influenza surveillance report for this season. Influenza surveillance reports will resume in October 2002 for the 2002/2003 influenza season.
National Disease Surveillance Centre (NDSC), National Virus Reference Laboratory (NVRL), Irish College of General Practitioners (ICGP)   +2 more
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

One Health Surveillance for SARS-CoV-2 in Non-Human Primates and Small Mammals in Minas Gerais, Brazil

Pathogens
Although the SARS-CoV-2 pandemic primarily affected the human population, the virus has also been detected in various animal species worldwide, raising concerns about its potential to establish new animal reservoirs.
Pedro Augusto Almeida-Souza, Thamires Gabriele Macedo Silva, Gabriele Barbosa Penha, Thaynara de Jesus Teixeira, Ramon Oliveira-Silva, Iago Alves Celestino, Maria Eduarda Gonçalves-dos-Santos, Cirilo Henrique de Oliveira, Alice dos Santos Nunes Ferreira, Emerson Márcio Gusmão, Vinícius de Oliveira Ottone, Danilo Simonini-Teixeira, Fabrício Souza Campos, Paulo Michel Roehe, Leonardo Camilo de Oliveira, Mauro Martins Teixeira, Filipe Vieira Santos de Abreu, Danilo Bretas de Oliveira   +17 more
doaj   +1 more source

Epidemiological and Molecular Investigation of the Heater–Cooler Unit (HCU)-Related Outbreak of Invasive Mycobacterium chimaera Infection Occurred in Italy

Microorganisms, 2023
Background: From 2013 onwards, a large outbreak of Mycobacterium chimaera (MC) invasive infection, which was correlated with the use of contaminated heater–cooler units (HCUs) during open chest surgery, was reported from all over the world.
Angela Cannas, Antonella Campanale, Daniela Minella, Francesco Messina, Ornella Butera, Carla Nisii, Antonio Mazzarelli, Carla Fontana, Lucia Lispi, Francesco Maraglino, Antonino Di Caro, Michela Sabbatucci   +11 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

A non-parametric approach to estimate multiplicity of infection and pathogen haplotype frequencies

Frontiers in Malaria
IntroductionThe presence of multiple genetically distinct variants (lineages) within an infection (multiplicity of infection, MOI) is common in infectious diseases such as malaria.
Loyce Kayanula, Kristan Alexander Schneider, Kristan Alexander Schneider, Kristan Alexander Schneider, Kristan Alexander Schneider   +4 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source