Results 1 to 10 of about 717,994 (294)

The Smallest Molecular Switch [PDF]

Physical Review Letters, 2003
Ab-initio total energy calculations reveal benzene-dithiolate (BDT) molecules on a gold surface, contacted by a monoatomic gold STM tip to have two classes of low energy conformations with differing symmetries.
Eldon G. Emberly, George Kirczenow, H. Sellers, M. Paulsson, M. H. Hettler, P. Damle, R. Landauer, R. Landauer, V. Mujica   +8 more
core   +4 more sources

Molecular switch‐mediated detection of EGFR deletion mutations and its application to cfDNA analysis [PDF]

Bioengineering & Translational Medicine
Sensitive and effective detection of epidermal growth factor receptor (EGFR) mutations is crucial for the early screening and diagnosis of non‐small cell lung cancer (NSCLC).
Ying‐ying Xu, Lu‐yan Wang, Sheng‐mei Zhou, Hui‐fen Xu, Wang‐yang Pu, Jun‐kang Shen, Chun‐gen Xing, Kai Li, Zhi‐yuan Qian, Li Xiao   +9 more
doaj   +2 more sources

Improving the Long-Range Intramolecular Proton Transfer—Further Molecular Design of the Successful Molecular Switch 8-(Benzo[d]thiazol-2-yl)quinolin-7-ol (HQBT) [PDF]

Molecules
Previously, we have described a successful molecular switch (8-(benzo[d]thiazol-2-yl)quinolin-7-ol), working on the basis of long-range proton transfer. Bearing in mind that its switching efficiency in low-polarity aprotic solvents is not sufficient, in ...
Daniela Nedeltcheva-Antonova, Liudmil Antonov   +1 more
doaj   +2 more sources

High performance mechano-optoelectronic molecular switch [PDF]

Nature Communications, 2023
Highly-efficient molecular photoswitching occurs ex-situ but not to-date inside electronic devices due to quenching of excited states by background interactions.
Zhenyu Yang, Pierre-André Cazade, Jin-Liang Lin, Zhou Cao, Ningyue Chen, Dongdong Zhang, Lian Duan, Christian A. Nijhuis, Damien Thompson, Yuan Li   +9 more
doaj   +2 more sources

A pH-Sensitive Peptide-Containing Lasso Molecular Switch

Molecules, 2013
The synthesis of a peptide-containing lasso molecular switch by a self-entanglement strategy is described. The interlocked [1] rotaxane molecular machine consists of a benzometaphenylene[25]crown-8 (BMP25C8) macrocycle surrounding a molecular axle.
Karine Fournel-Marotte, Caroline Clavel, Frédéric Coutrot   +2 more
doaj   +3 more sources

Bacterial Protein Homeostasis Disruption as a Therapeutic Intervention

Frontiers in Molecular Biosciences, 2021
Cells have evolved a complex molecular network, collectively called the protein homeostasis (proteostasis) network, to produce and maintain proteins in the appropriate conformation, concentration and subcellular localization.
Laleh Khodaparast, Laleh Khodaparast, Guiqin Wu, Guiqin Wu, Ladan Khodaparast, Ladan Khodaparast, Béla Z. Schmidt, Béla Z. Schmidt, Frederic Rousseau, Frederic Rousseau, Joost Schymkowitz, Joost Schymkowitz   +11 more
doaj   +1 more source

HPMPdb: A machine learning-ready database of protein molecular phenotypes associated to human missense variants

Current Research in Structural Biology, 2022
Current human Single Amino acid Variants (SAVs) databases provide a link between a SAVs and their effect on the carrier individual phenotype, often dividing them into Deleterious/Neutral variants. This is a very coarse-grained description of the genotype-
Daniele Raimondi, Francesco Codicè, Gabriele Orlando, Joost Schymkowitz, Frederic Rousseau, Yves Moreau   +5 more
doaj   +1 more source

MAPRE2 mutations result in altered human cranial neural crest migration, underlying craniofacial malformations in CSC-KT syndrome

Scientific Reports, 2021
Circumferential skin creases (CSC-KT) is a rare polymalformative syndrome characterised by intellectual disability associated with skin creases on the limbs, and very characteristic craniofacial malformations.
Cedric Thues, Jorge S. Valadas, Liesbeth Deaulmerie, Ann Geens, Amit K. Chouhan, Ramon Duran-Romaña, Joost Schymkowitz, Frederic Rousseau, Michaela Bartusel, Rizwan Rehimi, Alvaro Rada-Iglesias, Patrik Verstreken, Hilde Van Esch   +12 more
doaj   +1 more source

The Versatile Photo-Thermal Behaviour of a 2-Hydroxyazobenzene

Molecules, 2023
Photochromic compounds are employed in implementing neuron surrogates. They will boost the development of neuromorphic engineering in wetware. In this work, the photochromic behaviours of (E)-3,4,6-trichloro-2-(p-diazenil)-phenol (t-DZH) and its ...
Pier Luigi Gentili, Antonio Capaccioni, Raimondo Germani, Simona Fantacci   +3 more
doaj   +1 more source

Entropic Bristles Tune the Seeding Efficiency of Prion-Nucleating Fragments

Cell Reports, 2020
Summary: Prions of lower eukaryotes are self-templating protein aggregates with cores formed by parallel in-register beta strands. Short aggregation-prone glutamine (Q)- and asparagine (N)-rich regions embedded in longer disordered domains have been ...
Emiel Michiels, Shu Liu, Rodrigo Gallardo, Nikolaos Louros, Marion Mathelié-Guinlet, Yves Dufrêne, Joost Schymkowitz, Ina Vorberg, Frederic Rousseau   +8 more
doaj   +1 more source