Results 21 to 30 of about 717,994 (294)

Structural hot spots for the solubility of globular proteins

Nature Communications, 2016
Mutations in aggregation prone regions of recombinant proteins often improve their solubility, although they might cause negative effects on their structure and function.
Ashok Ganesan, Aleksandra Siekierska, Jacinte Beerten, Marijke Brams, Joost Van Durme, Greet De Baets, Rob Van der Kant, Rodrigo Gallardo, Meine Ramakers, Tobias Langenberg, Hannah Wilkinson, Frederik De Smet, Chris Ulens, Frederic Rousseau, Joost Schymkowitz   +14 more
doaj   +1 more source

Signal Recognition Particle (SRP) and SRP Receptor: A New Paradigm for Multistate Regulatory GTPases [PDF]

, 2009
The GTP-binding proteins or GTPases comprise a superfamily of proteins that provide molecular switches in numerous cellular processes. The “GTPase switch” paradigm, in which a GTPase acts as a bimodal switch that is turned “on” and “off” by external ...
Schmid, Sandra L., Shan, Shu-ou, Zhang, Xin   +2 more
core   +2 more sources

Proton switching molecular magnetoelectricity [PDF]

Nature Communications, 2021
AbstractThe convergence of proton conduction and multiferroics is generating a compelling opportunity to achieve strong magnetoelectric coupling and magneto-ionics, offering a versatile platform to realize molecular magnetoelectrics. Here we describe machine learning coupled with additive manufacturing to accelerate the design strategy for hydrogen ...
Yong Hu, Scott Broderick, Zipeng Guo, Alpha T. N’Diaye, Jaspal S. Bola, Hans Malissa, Cheng Li, Qiang Zhang, Yulong Huang, Quanxi Jia, Christoph Boehme, Z. Valy Vardeny, Chi Zhou, Shenqiang Ren   +13 more
openaire   +5 more sources

Dynamic control of selectivity in the ubiquitination pathway revealed by an ASP to GLU substitution in an intra-molecular salt-bridge network [PDF]

, 2012
Ubiquitination relies on a subtle balance between selectivity and promiscuity achieved through specific interactions between ubiquitin-conjugating enzymes (E2s) and ubiquitin ligases (E3s).
Bonvin, Alexandre M. J. J., Melquiond, Adrien S. J., Timmers, H. Th. Marc, Vries, Sjoerd J. de, Wijk, Sjoerd van   +4 more
core   +3 more sources

Molecular switches and cages [PDF]

Beilstein Journal of Organic Chemistry, 2012
Molecular switches can toggle between two (or more) stable states encoding different physical features. They allow complex systems to respond to changes in their environment defined by light intensity, pH, temperature or voltage. As such, molecular switches play a key role in biology and information technology and have become important components of ...
openaire   +3 more sources

Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis

Nature Communications, 2018
Aggregation is sequence-specific and nucleated by short aggregating protein segments (APR). Here authors use a multidisciplinary approach to show that in E.coli some frequently occurring APRs lead to protein aggregation and ultimately bacterial cell ...
Ladan Khodaparast, Laleh Khodaparast, Rodrigo Gallardo, Nikolaos N. Louros, Emiel Michiels, Reshmi Ramakrishnan, Meine Ramakers, Filip Claes, Lydia Young, Mohammad Shahrooei, Hannah Wilkinson, Matyas Desager, Wubishet Mengistu Tadesse, K. Peter R. Nilsson, Per Hammarström, Abram Aertsen, Sebastien Carpentier, Johan Van Eldere, Frederic Rousseau, Joost Schymkowitz   +19 more
doaj   +1 more source

Dual Modulation of Single Molecule Conductance via Tuning Side Chains and Electric Field with Conjugated Molecules Entailing Intramolecular O•••S Interactions

Advanced Science, 2022
Herein, single‐molecule conductance studies of TBT1‐TBT6 which entails 1,4‐dithienylbenzene as the backbone and SMe groups as the anchoring units, with the scanning tunneling microscope break junction (STM‐BJ) technique, are reported.
Hua Zhang, Wei Xu, Kai Song, Taige Lu, Guanxin Zhang, Yaping Zang, Wenjing Hong, Deqing Zhang   +7 more
doaj   +1 more source

Resonant Electron Tunneling Induces Isomerization of π‐Expanded Oligothiophene Macrocycles in a 2D Crystal

Advanced Science, 2022
Macrocyclic oligothiophenes and their π‐expanded derivatives constitute versatile building blocks for the design of (supra)molecularly engineered active interfaces, owing to their structural, chemical, and optoelectronic properties.
José D. Cojal González, Masahiko Iyoda, Jürgen P. Rabe   +2 more
doaj   +1 more source

Comprehensive subcellular topologies of polypeptides in Streptomyces

Microbial Cell Factories, 2018
Background Members of the genus Streptomyces are Gram-positive bacteria that are used as important cell factories to produce secondary metabolites and secrete heterologous proteins.
Konstantinos C. Tsolis, Evridiki-Pandora Tsare, Georgia Orfanoudaki, Tobias Busche, Katerina Kanaki, Reshmi Ramakrishnan, Frederic Rousseau, Joost Schymkowitz, Christian Rückert, Jörn Kalinowski, Jozef Anné, Spyridoula Karamanou, Maria I. Klapa, Anastassios Economou   +13 more
doaj   +1 more source

One Scaffold, Two Conformations: The Ring-Flip of the Messenger InsP₈ Occurs under Cytosolic Conditions

Biomolecules, 2023
Inositol poly- and pyrophosphates (InsPs and PP-InsPs) are central eukaryotic messengers. These very highly phosphorylated molecules can exist in two distinct conformations, a canonical one with five phosphoryl groups in equatorial positions, and a ...
Leonie Kurz, Peter Schmieder, Nicolás Veiga, Dorothea Fiedler   +3 more
doaj   +1 more source