Results 21 to 30 of about 5,797,712 (321)

Entropic Bristles Tune the Seeding Efficiency of Prion-Nucleating Fragments

Cell Reports, 2020
Summary: Prions of lower eukaryotes are self-templating protein aggregates with cores formed by parallel in-register beta strands. Short aggregation-prone glutamine (Q)- and asparagine (N)-rich regions embedded in longer disordered domains have been ...
Emiel Michiels, Shu Liu, Rodrigo Gallardo, Nikolaos Louros, Marion Mathelié-Guinlet, Yves Dufrêne, Joost Schymkowitz, Ina Vorberg, Frederic Rousseau   +8 more
doaj   +1 more source

A molecular switch for neuroprotective astrocyte reactivity. [PDF]

Nature, 2023
Cameron EG, Nahmou M, Toth AB, Heo L, Tanasa B, Dalal R, Yan W, Nallagatla P, Xia X, Hay S, Knasel C, Stiles TL, Douglas C, Atkins M, Sun C, Ashouri M, Bian M, Chang KC, Russano K, Shah S, Woodworth MB, Galvao J, Nair RV, Kapiloff MS, Goldberg JL.   +24 more
europepmc   +2 more sources

Radically Enhanced Molecular Switches [PDF]

Journal of the American Chemical Society, 2012
The mechanism governing the redox-stimulated switching behavior of a tristable [2]rotaxane consisting of a cyclobis(paraquat-p-phenylene) (CBPQT(4+)) ring encircling a dumbbell, containing tetrathiafulvalene (TTF) and 1,5-dioxynaphthalene (DNP) recognition units which are separated from each other along a polyether chain carrying 2,6-diisopropylphenyl ...
Fahrenbach, Albert C., Zhu, Zhixue, Cao, Dennis, Liu, Wei-Guang, Li, Hao, Dey, Sanjeev K., Basu, Subhadeep, Trabolsi, Ali, Botros, Youssry Y., Goddard, William A., III, Stoddart, J. Fraser   +10 more
openaire   +3 more sources

Theoretical calculations of an osmium molecular switch [PDF]

, 2013
Indexación: Web of Science; Scielo.ABSTRACT We have investigated the molecular, electronic and optical properties of the [Os(tpy-py)2]2+ complex (tpy-py = 4'-(4-pyridyl)-2,2':6',2"-terpyridine) and its protonated derivative [Os(tpy-pyH)2]4+ through ...
Arratia-Pérez, Ramiro, Miranda-Barrientos, Fernando, Muñoz-Castro, Alvaro   +2 more
core   +1 more source

Molecular Magnetic Switches

CHIMIA, 2019
The design and synthesis of molecular switches is of growing importance considering the steep increase in the production of consumer electronics in the recent years. The function of these devices is based on binary electronic circuits and can be achieved by use of bistable magnetic materials.
Čavlović, Daniel, Juricek, Michal
openaire   +5 more sources

Novel Indoline Spiropyrans Based on Human Hormones β-Estradiol and Estrone: Synthesis, Structure, Chromogenic and Cytotoxic Properties

Molecules, 2023
The introduction of a switchable function into the structure of a bioactive compound can endow it with unique capabilities for regulating biological activity under the influence of various types of external stimuli, which makes such hybrid compounds ...
Ilya V. Ozhogin, Artem D. Pugachev, Nadezhda I. Makarova, Anna A. Belanova, Anastasia S. Kozlenko, Irina A. Rostovtseva, Peter V. Zolotukhin, Oleg P. Demidov, Islam M. El-Sewify, Gennady S. Borodkin, Anatoly V. Metelitsa, Boris S. Lukyanov   +11 more
doaj   +1 more source

Electrically gated molecular thermal switch

Science, 2023
Controlling heat flow is a key challenge for applications ranging from thermal management in electronics to energy systems, industrial processing, and thermal therapy. However, progress has generally been limited by slow response times and low tunability
Man Li, Huann-Der Wu, Erin M. Avery, Zihao Qin, D. P. Goronzy, Huuduy Nguyen, Tianhan Liu, Paul S. Weiss, Yongjie Hu   +8 more
semanticscholar   +1 more source

Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production [PDF]

, 2016
Self-tolerance and immunity are actively acquired in parallel through a poorly understood ability of antigen receptors to switch between signaling death or proliferation of antigenbinding lymphocytes in different contexts.
Domaschenz, Heather, Fung, Herman, Goodnow, Christopher, Horikawa, Keisuke, Jeelall, Yogeshraj, Kallies, Axel, Law, Hsei-Di, Nutt, Stephen L, Wang, James   +8 more
core   +1 more source

Indandiazocines: unidirectional molecular switches [PDF]

ScienceOpen Research, 2015
Abstract We report theoretical investigations on azobenzene-based indandiazocines, novel chiral systems that perform unidirectional cis ↔ trans isomerizations upon photoexcitation.
Bernd Hartke, Tim Raeker
openaire   +2 more sources

Structural hot spots for the solubility of globular proteins

Nature Communications, 2016
Mutations in aggregation prone regions of recombinant proteins often improve their solubility, although they might cause negative effects on their structure and function.
Ashok Ganesan, Aleksandra Siekierska, Jacinte Beerten, Marijke Brams, Joost Van Durme, Greet De Baets, Rob Van der Kant, Rodrigo Gallardo, Meine Ramakers, Tobias Langenberg, Hannah Wilkinson, Frederik De Smet, Chris Ulens, Frederic Rousseau, Joost Schymkowitz   +14 more
doaj   +1 more source