Results 51 to 60 of about 717,994 (294)
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Local structural preferences in shaping tau amyloid polymorphism
Nature CommunicationsTauopathies encompass a group of neurodegenerative disorders characterised by diverse tau amyloid fibril structures. The persistence of polymorphism across tauopathies suggests that distinct pathological conditions dictate the adopted polymorph for each ...
Nikolaos Louros +16 more
doaj +1 more source
An azobenzene container showing a definite folding – synthesis and structural investigation
Beilstein Journal of Organic Chemistry, 2019 The combination of photo-switchable units with macrocycles is a very interesting field in supramolecular chemistry. Here, we present the synthesis of a foldable container consisting of two different types of Lissoclinum macrocyclic peptides which are ...
Abdulselam Adam +2 more
doaj +1 more source
Dissipation enhanced vibrational sensing in an olfactory molecular switch
, 2015 Motivated by a proposed olfactory mechanism based on a vibrationally-activated molecular switch, we study electron transport within a donor-acceptor pair that is coupled to a vibrational mode and embedded in a surrounding environment. We derive a polaron
Agata Chęcińska +8 more
core +1 more source
Nitrogenase: A nucleotide-dependent molecular switch [PDF]
, 1994 In the simplest terms, the biological nitrogen cycle is the reduction of atmospheric dinitrogen (N2) to ammonia with the subsequent reoxidation ammonia to dinitrogen (1).
Howard, James B., Rees, Douglas C.
core +1 more source
Indandiazocines: unidirectional molecular switches [PDF]
ScienceOpen Research, 2015 Abstract We report theoretical investigations on azobenzene-based indandiazocines, novel chiral systems that perform unidirectional cis ↔ trans isomerizations upon photoexcitation.
Bernd Hartke, Tim Raeker
openaire +2 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling
Nature Communications, 2016 PDZ domain-containing proteins are known to function as intracellular scaffolds. Here, Egea-Jimenez et al. report the structure of the tandem PDZ domains of syntenin in complex with a Frizzled 7 peptide and PIP2, show that the ligands bind to syntenin ...
Antonio Luis Egea-Jimenez +9 more
doaj +1 more source
Molecules, 2020 We report data on the structural dynamics of the neuropeptide Y (NPY) G-protein-coupled receptor (GPCR) type 1 (Y1R), a typical representative of class A peptide ligand GPCRs, using a combination of solid-state NMR and molecular dynamics (MD) simulation.
Alexander Vogel +9 more
doaj +1 more source
Light‐Fueled Climbing of Monolithic Torsional Soft Robots via Molecular Engineering
Advanced Intelligent Systems, 2022 Azobenzene‐functionalized liquid crystalline polymer networks (azo‐LCNs) are promising candidates for light‐fueled contactless manipulation of miniaturized soft robots through embedding photoactive molecular switches into alignment‐programmable LCNs.
Jae Gwang Kim +7 more
doaj +1 more source