Results 71 to 80 of about 717,994 (294)
EJNMMI Radiopharmacy and ChemistryBackground The extracellular localisation of the Heat shock protein 90 (Hsp90) is associated with the diseased state and wound healing and presents a promising opportunity for cancer targeting using Positron Emission Tomography (PET) imaging and ...
Valeria Narykina +5 more
doaj +1 more source
Folding and Stability of Ankyrin Repeats Control Biological Protein Function
Biomolecules, 2021 Ankyrin repeat proteins are found in all three kingdoms of life. Fundamentally, these proteins are involved in protein-protein interaction in order to activate or suppress biological processes. The basic architecture of these proteins comprises repeating
Amit Kumar, Jochen Balbach
doaj +1 more source
Quantification of finite-temperature effects on adsorption geometries of $\pi$-conjugated molecules [PDF]
, 2013 The adsorption structure of the molecular switch azobenzene on Ag(111) is investigated by a combination of normal incidence x-ray standing waves and dispersion-corrected density functional theory. The inclusion of non-local collective substrate response (
Hagen, S. +10 more
core +3 more sources
Molecular switch of EZH2 in hypoxia [PDF]
Cell Cycle, 2016 Over the past decades, several reports on a non-canonical function of Ezh2 and discoveries of its novel partners, other than its canonical PRC2 members i.e.
Sylvia, Mahara, Wee Joo, Chng, Qiang, Yu
openaire +2 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Radically Enhanced Molecular Switches [PDF]
Journal of the American Chemical Society, 2012 The mechanism governing the redox-stimulated switching behavior of a tristable [2]rotaxane consisting of a cyclobis(paraquat-p-phenylene) (CBPQT(4+)) ring encircling a dumbbell, containing tetrathiafulvalene (TTF) and 1,5-dioxynaphthalene (DNP) recognition units which are separated from each other along a polyether chain carrying 2,6-diisopropylphenyl ...
Fahrenbach, Albert C. +10 more
openaire +3 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Functional Conservation of the Small GTPase Rho5/Rac1—A Tale of Yeast and Men
CellsSmall GTPases are molecular switches that participate in many essential cellular processes. Amongst them, human Rac1 was first described for its role in regulating actin cytoskeleton dynamics and cell migration, with a close relation to carcinogenesis ...
Linnet Bischof +2 more
doaj +1 more source
Redox-Dependent Conformational Switching of Diphenylacetylenes
Molecules, 2014 Herein we describe the design and synthesis of a redox-dependent single-molecule switch. Appending a ferrocene unit to a diphenylacetylene scaffold gives a redox-sensitive handle, which undergoes reversible one-electron oxidation, as demonstrated by ...
Ian M. Jones +4 more
doaj +1 more source