Results 111 to 120 of about 3,557,904 (289)

London dispersion as important factor for the stabilization of (Z)-azobenzenes in the presence of hydrogen bonding

Beilstein Journal of Organic Chemistry, 2018
The understanding and control of the light-induced isomerization of azobenzenes as one of the most important classes of molecular switches is crucial for the design of light-responsive materials using this entity.
Andreas H. Heindl, Raffael C. Wende, Hermann A. Wegner   +2 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

A bisazobenzene crosslinker that isomerizes with visible light

Beilstein Journal of Organic Chemistry, 2012
Background: Large conformational and functional changes of azobenzene-modified biomolecules require longer azobenzene derivatives that undergo large end-to-end distance changes upon photoisomerization.
Subhas Samanta, Harris I. Qureshi, G. Andrew Woolley   +2 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Phenazine-1,6-dicarboxamides: Redox-Responsive Molecular Switches

, 2019
We introduce phenazine-1,6-dicarboxamides as redox-responsive molecular switches. The reduction of their phenazine core transforms them from hydrogen-bond acceptors into hydrogen-bond donors and thus forces the secondary amide substituents to turn around.
Ali N. Khalilov (8189673), Pandi Muthupandi (1457557), Jingwei Yin (8189670), Ruby Ladd (8189676), Vladimir B. Birman (1951207)   +4 more
core   +2 more sources

Switchable molecular tweezers: design and applications

Beilstein Journal of Organic Chemistry
Switchable molecular tweezers are a unique class of molecular switches that, like their macroscopic analogs, exhibit mechanical motion between an open and closed conformation in response to stimuli.
Pablo Msellem, Maksym Dekthiarenko, Nihal Hadj Seyd, Guillaume Vives   +3 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Molecular switches based on iron complexes with functionalized scorpionate ligands

reservedThis master thesis project consists in the synthesis and characterization of molecular switches, specifically the focus is on monometallic spin-crossover (SCO) complexes of Fe(II) with fac-tridentate ligands from the "scorpionate" family, and on ...
CAMPAGNA, FRANCESCA
core  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

The art of building small: from molecular switches to molecular motors

, 2007
Molecular switches and motors are essential components of artificial molecular machines. In this perspective, we discuss progress in our design, synthesis, and functioning of photochemical and electrochemical switches and chemical and light-driven ...
Ben L. Feringa, Feringa, Bernard, Feringa, Ben L.   +2 more
core   +1 more source