Results 101 to 110 of about 3,557,904 (289)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Nanoscale Energy Storage and Conversion:Powered by Molecular Switches [PDF]
Molecular switches—tiny chemical compounds that change structure in response to light or chemicals—are unlocking new possibilities in energy storage, bioimaging, and smart materials.
Weber, Roza R.; id_orcid
core +1 more source
Targeted photoswitchable imaging of intracellular glutathione by a photochromic glycosheet sensor
Beilstein Journal of Organic Chemistry, 2019 The development of photochromic fluorescence sensors with dynamic and multiple-signaling is beneficial to the improvement of biosensing/imaging precision.
Xianzhi Chai +6 more
doaj +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Confined molecular machines and switches [PDF]
, 2019 Nature has evolved a complex molecular machinery that orchestrates nearly all aspects of metabolism ranging from protein synthesis to cellular locomotion.
Danowski, Wojtek
core +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Signal Communication between Molecular Switches
, 2001 Efficient strategies for the communication of signals between molecules must be identified for the development of molecule-based nanoprocessors. We have demonstrated that photoinduced proton transfer can be exploited to implement intermolecular digital ...
Giordani, Silvia +3 more
core +1 more source
A combinatorial approach to improving the performance of azoarene photoswitches
Beilstein Journal of Organic Chemistry, 2019 Azoarenes remain privileged photoswitches – molecules that can be interconverted between two states using light – enabling a huge range of light addressable multifunctional systems and materials.
Joaquin Calbo +4 more
doaj +1 more source
Analog Signaling With the “Digital” Molecular Switch CaMKII
Frontiers in Computational Neuroscience, 2018 Molecular switches, such as the protein kinase CaMKII, play a fundamental role in cell signaling by decoding inputs into either high or low states of activity; because the high activation state can be turned on and persist after the input ceases, these ...
Stephen E. Clarke
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source