Results 51 to 60 of about 3,557,904 (289)
Improved DFT for Testing Power Switches [PDF]
, 2011 Power switches are used as part of power-gating technique to reduce leakage power of a design. To the best of our knowledge this is the first study that analyzes recently proposed DFT solutions for testing power switches through SPICE simulations on a ...
Yang, Sheng +4 more
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Amino-substituted diazocines as pincer-type photochromic switches
Beilstein Journal of Organic Chemistry, 2013 Azobenzenes are robust, reliable, and easy to synthesize photochromic switches. However, their high conformational flexibility is a disadvantage in machine-like applications. The almost free rotation of the phenyl groups can be restricted by bridging two
Hanno Sell +2 more
doaj +1 more source
Molecules, 2021 Functional molecule-based solids built of metal complexes can reveal a great impact of external stimuli upon their optical, magnetic, electric, and mechanical properties. We report a novel molecular material, {[EuIII(H2O)3(pyrone)4][CoIII(CN)6]}·nH2O (1,
Jakub J. Zakrzewski +3 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Molecular switches facilitate rhythms in the circadian clock of Neurospora crassa [PDF]
, 2021 Zirkadiane Rhythmen haben sich in allen Lebensbereichen aufgrund täglicher Wechselwirkungen zwischen internen Zeitgebern und Umweltreizen entwickelt. Molekulare Oszillatoren bestehen aus einer Transkriptions-Translations-Rückkopplungsschleife (TTFL), die
Upadhyay, Abhishek
core +1 more source
Thermodynamics and Kinetics of Guest-Induced Switching between “Basket Handle” Porphyrin Isomers
Molecules, 2014 The synthesis and switching properties of two “basket handle” porphyrin isomers is described. The cis-oriented meso-phenyl groups of these porphyrins are linked at their ortho-positons via benzocrown-ether-based spacers, which as a result of slow ...
Alexander B. C. Deutman +6 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
The molecular switches : types and applications [PDF]
, 2015 A subject of this work is group of organic compounds known as molecular switches. Molecular switches are described as chemical compounds which molecules have at least two thermodynamically stable states.
Bartyzel, K.
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