Results 311 to 320 of about 957,553 (357)
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Targeted Molecular Therapy in Melanoma
Seminars in Cutaneous Medicine and Surgery, 2010Immunotherapy and chemotherapy benefit few patients with metastatic melanoma, and even fewer experience durable survival benefit. These poor results may come from treating all melanomas as though they are biologically homogeneous. Recently, it has been shown that targeting specific activated tyrosine kinases (oncogenes) can have striking clinical ...
Igor, Puzanov, Keith T, Flaherty
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2019
The treatment of advanced thyroid cancer has developed with increased understanding of the molecular basis of the disease. Alongside this targeted therapies have been developed, and there is evidence of efficacy for multikinase inhibitors in improving progression-free survival in this population of patients.
Arabella Hunt, Kate L. Newbold
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The treatment of advanced thyroid cancer has developed with increased understanding of the molecular basis of the disease. Alongside this targeted therapies have been developed, and there is evidence of efficacy for multikinase inhibitors in improving progression-free survival in this population of patients.
Arabella Hunt, Kate L. Newbold
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Molecular Targets for Papillomavirus Therapy
Current Drug Target -Infectious Disorders, 2003Papillomaviruses are infectious agents for human and animal epithelial tissue, and nearly 100 distinct human types (HPVs) have been identified. When these viruses infect cutaneous or mucosal skin they can initially cause clinical warts or persistent infection with little or no visible manifestations.
V G, Wilson, G, Rosas-Acosta
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Molecular Targets of Antiviral Therapy
New England Journal of Medicine, 1989THE development of specific antiviral drugs that are minimally toxic to normal cells has ushered in a new era of antiviral therapy.
Jeffrey S. Flier +2 more
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Combining molecular targeted therapies
Anti-Cancer Drugs, 2011Approximately 20 molecular targeted therapies, mainly monoclonal antibodies and tyrosine kinase inhibitors, have been approved for the treatment of various cancers. They are being increasingly investigated in combination in clinical trials. We review the rationale for combining molecular targeted therapies and the results of clinical trials to date ...
Xavier, Pivot +4 more
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Molecular Targets and Targeted Therapies for Malignant Mesothelioma
Current Medicinal Chemistry, 2008Malignant mesothelioma is a highly invasive tumor originating from the mesothelial linings of the pleura, peritoneum and pericardium. It is seldom amenable to surgical intervention and poorly responsive to radiotherapy, leaving chemotherapy as the main therapeutic option for most patients. The development of effective drug regimens against mesothelioma
PALUMBO, CAMILLA +3 more
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[Molecular targeted therapies].
Nihon rinsho. Japanese journal of clinical medicine, 2010Current treatment paradigms in cancer patients are shifting from cytotoxic chemotherapies alone to single-agent and combination biological and targeted therapies. Targeted therapies are entering standard treatment paradigms. As patient responses to targeted therapies vary, predictive biomarkers will be an important tool of a patient's diagnostic workup
Hideharu, Kimura, Kazuto, Nishio
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Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 2007
Until recently, cancer therapy was based on three modalities: surgery, radiotherapy, and cytostatic chemotherapy. In most instances treatment of solid tumors was a surgical domain. For patients with incomplete resection or relapse after surgery, radiotherapy and chemotherapy usually offered only partial response and mostly of limited duration.
F, Stenner-Liewen +3 more
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Until recently, cancer therapy was based on three modalities: surgery, radiotherapy, and cytostatic chemotherapy. In most instances treatment of solid tumors was a surgical domain. For patients with incomplete resection or relapse after surgery, radiotherapy and chemotherapy usually offered only partial response and mostly of limited duration.
F, Stenner-Liewen +3 more
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Molecular targets in cancer therapy
Seminars in Oncology Nursing, 2003To review selected pharmacologic agents that target key cellular processes along with their mechanisms of action and adverse events. Nursing implications including what patients and families need to know, administration issues, and management of common toxicities will be reviewed.Research articles, clinical trials, abstracts, and book chapters ...
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Molecular Targeting of Lymphatics for Therapy
Current Pharmaceutical Design, 2004The dysfunction or proliferation of lymphatic vessels (lymphangiogenesis) is linked to a number of pathological conditions including lymphedema and cancer. The recent discovery and characterisation of the lymphangiogenic growth factors vascular endothelial growth factor-C (VEGF-C) and VEGF-D and of their receptor on lymphatic endothelial cells, VEGFR-3,
S A, Stacker, R A, Hughes, M G, Achen
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