Results 71 to 80 of about 1,370,451 (310)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The Importance of Brain Banks for Molecular Neuropathological Research: The New South Wales Tissue Resource Centre Experience

, 2009
New developments in molecular neuropathology have evoked increased demands for postmortem human brain tissue. The New South Wales Tissue Resource Centre (TRC) at The University of Sydney has grown from a small tissue collection into one of the leading ...
Donna Sheedy, Antony Harding, Clive G. Harper, Clare Hunt, Irina Dedova, Nina Sundqvist, Therese Garrick, Juliette Gillies   +7 more
core   +1 more source

Molecular Diagnostic Techniques of Infectious Diseases

Philippine Journal of Pathology
Recent advancements in molecular techniques such as real-time PCR, isothermal amplification, next-generation sequencing, metagenomics, microarray, and CRISPR-based infectious disease diagnostics have significantly evolved and improved over the past ...
Michael Baclig
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Molecular Docking in Drug Discovery: Techniques, Applications, and Advancements

Objective: The primary objective of this study is to conduct a comprehensive review of the significance of molecular docking in the field of drug discovery.
Ihosvany, Camps, Cinthia, Aguiar
core   +1 more source

Linear and nonlinear spectroscopic techniques applied to study of transient molecular species [PDF]

, 2011
Carbon chain radicals and ions have long been known to exist in the interstellar medium, and considered as potential carriers for diffuse interstellar bands.
Raghunandan, Ranjini
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Tagged repair techniques for defect tolerance in hybrid nano/CMOS architecture

, 2010
We propose two new repair techniques for hybrid nano/CMOS computing architecture with lookup table based Boolean logic. Our proposed techniques use tagging mechanism to provide high level of defect tolerance and we present theoretical equations to ...
Srivastava, Saket, Melouki, Aissa, Saket Srivastava, Bashir M. Al-Hashimi, Al-Hashimi, Bashir, Aissa Melouki   +5 more
core   +1 more source

Fungal-Infected Weeds: A Potential Source of Leaf Spot Disease in Rubber Trees from Southern Thailand

Journal of Fungi
The rubber tree (Hevea brasiliensis) is an economically important crop in Thailand. Severe defoliation caused by emerging diseases has been reported to substantially reduce rubber yields during the leaf fall phase.
Narit Thaochan, Chaninun Pornsuriya, Thanunchanok Chairin, Kodeeyah Thoawan, Putarak Chomnunti, Anurag Sunpapao   +5 more
doaj   +1 more source

Molecular Techniques in Mycobacterial Detection

Archives of Pathology & Laboratory Medicine, 2001
Abstract Objective. —To assess the clinical utility of the commercial nucleic acid amplification (NAA) tests (ie, Amplified Mycobacterium Tuberculosis Direct Test, Gen-Probe, Inc and AMPLICOR Mycobacterium tuberculosis Test, Roche Molecular Systems, Inc ...
openaire   +2 more sources