Results 171 to 180 of about 15,380,906 (402)

Virtual Insights into Natural Compounds as Potential 5α-Reductase Type II Inhibitors: A Structure-Based Screening and Molecular Dynamics Simulation Study [PDF]

, 2023
Sibhghatulla Shaikh, Shahid Ali, Jeong Ho Lim, Khurshid Ahmad, Ki Soo Han, Eun Ju Lee, Inho Choi   +6 more
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Successful DNA Profiling for Identification of burnt Families from their bones using AmpFℓSTR Identifiler® Plus Kit

Advancements in Life Sciences, 2016
Background: DNA profiling plays a vital role in the identification of dead bodies during mass disasters. Severe fragmentation, decomposition, burning and intermixing of the remains can occur in the mass disasters.
Muhamamd Shahzad, Muhammad Shafique, Manzoor Hussain, Muhammad Adnan Shan, Rukhsana Perveen, Ziaurehman, Muhammad Idrees   +6 more
doaj  

Linajes de Trypanosoma cruzi en pacientes con enfermedad de Chagas y coinfección por VIH [PDF]

, 2009
Introducción. Las poblaciones naturales de T. cruzi han sido clasificadas en seis linajes filogenéticos o unidades de tipificación discreta: T. cruzi I, IIa, IIb, IIc, IId y IIe, que pueden jugar un rol en el tropismo tisular y patogénesis de la ...
Altcheh, Jaime Marcelo, Begher, Sandra, Bisio, Margarita María Catalina, Burgos, Juan Miguel, Cura, Carolina Inés, Duffy, Tomás, Freilij, Hector León, Giganti, Salvador Óscar, Levin, Mariano Jorge, Scapellato, Pablo Gustavo, Schijman, Alejandro Gabriel, Schreck, Ricardo   +11 more
core  

An Update on the Molecular and Cellular Basis of Pharmacotherapy in Type 2 Diabetes Mellitus [PDF]

, 2023
Mohamed Mahgoub, Ifrah I. Ali, Jennifer Adeghate, Kornélia Tekes, Huba Kalász, Ernest Adeghate   +5 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Multiresistant Salmonella enterica serovar 4,[5],12:i:- in Europe: a new pandemic strain? [PDF]

, 2010
A marked increase in the prevalence of S. enterica serovar 4,[5],12:i:- with resistance to ampicillin, streptomycin, sulphonamides and tetracyclines (R-type ASSuT) has been noted in food-borne infections and in pigs/pig meat in several European countries
Granier, A., Guerra, B., Hopkins, K.L., Jakubczak, A., Kirchner, M., Lucarelli, C., Mevius, D.J., Porrero, M.C., Threlfall, J.   +8 more
core   +3 more sources

Targeting molecular tumor types [PDF]

Nature Genetics, 2013
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Isolation of pathogenic leptospires from blood samples of patients by PCR- RFLP method

مجله دانشگاه علوم پزشکی گرگان, 2010
Background and Objective: Leptospirosis is a worldwide zoonosis that is more common in tropical and semitropical regions and in flat area of Guilan province, nothern Iran, caused by pathogenic leptospires.Serotyping by MAT is complicated, expensive and ...
Honarmand HR (PhD), Khayat L (MSc), Mansour Ghanaei F (PhD), Rahbar Taromsari M (MD)   +3 more
doaj