Results 221 to 230 of about 15,380,906 (402)

Research progress of molecular typing and targeted therapy for triple-negative breast cancer. [PDF]

Front Oncol
Xiang DL, Yue X.
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Epidemiology and molecular typing of multidrug resistant Acinetobacter baumannii burn wound isolates from six Chinese provinces. [PDF]

Sci Rep
Pan S, Liu K, Huang Y, Gong Y, Wang J, Lei Z, Yang Z.   +6 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Molecular Typing of <i>Clostridium botulinum</i> Isolated from Chili Pepper Preserves During a Botulism Outbreak. [PDF]

Foods
Arnaboldi S, Benevenia R, Monastero P, Bornati L, Magagna G, Losio MN, Finazzi G.   +6 more
europepmc   +1 more source

Molecular Typing on Human Blood Reveals the Borrelia afzelii Infection in Korea. [PDF]

Infect Chemother, 2023
Kim YS, Kim J, Choi YJ, Kang T, Park HJ, Jang WJ.   +5 more
europepmc   +1 more source

955 Unveiling Molecular Signatures and Discovering Sensitive-Specific Diagnostic Biomarkers for Endocervical Gastric-type Adenocarcinoma through Integrated Transcriptome and DNA Methylation Profiling [PDF]

Ling Chen, Bingbing Liu, Yanning Xu, Zhengmao Zhu, Chengquan Zhao   +4 more
openalex   +1 more source

Molecular Basis for the Unique Role of the AAA+ Chaperone ClpV in Type VI Protein Secretion [PDF]

, 2011
Aleksandra Pietrosiuk, Esther D. Lenherr, Sebastian Falk, Gabriele Bönemann, Jürgen Kopp, Hanswalter Zentgraf, Irmgard Sinning, Axel Mogk   +7 more
openalex   +1 more source

Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms.

Proceedings of the National Academy of Sciences of the United States of America, 1998
M. Maiden, J. Bygraves, E. Feil, G. Morelli, J. Russell, R. Urwin, Qing Zhang, Jiaji Zhou, Kerstin Zurth, D. Caugant, I. Feavers, M. Achtman, B. Spratt   +12 more
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source