Results 181 to 190 of about 1,767,737 (317)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Low molecular weight chitosan nanoparticulate system at low N:P ratio for nontoxic polynucleotide delivery

, 2012
Mohamad Alameh, Diogo DeJesus, Myriam Jean, Vincent Darras, Marc Thibault, Marc Lavertu, Michael D Buschmann, Abderrazzak MerzoukiInstitute of Biomedical Engineering, Department of Chemical Engineering, École Polytechnique, Montréal,
Buschmann MD, Lavertu M, Merzouki A, Alameh M, Jean M, Thibault M, Darras V, DeJesus D   +7 more
core  

Low molecular weight 4,4'-quinocyanines for in vivo NIR-II fluorescence imaging. [PDF]

Npj Imaging
Isuri RK, Hart MC, Adusei-Poku S, Dudek GC, Delikatny EJ, Popov AV.   +5 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Sternal Re-Closure for Refractory Dehiscence Using Ultra-High Molecular Weight Polyethylene Tape. [PDF]

Interdiscip Cardiovasc Thorac Surg
Niki T, Nakahara Y, Iwakura T, Marui A.
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Tailored molecular weight hyaluronic acid production by engineered Lactococcus lactis. [PDF]

Microb Cell Fact
Soundiraraj S, Ravishankar N, Jeeva P, Blank LM, Jayaraman G.   +4 more
europepmc   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Sonication-Freezing-Assisted Extraction of Chia Seed Mucilage: Functional and Structure-Rheology Relationships and Molecular Weight Determination. [PDF]

Gels
Sanpedro-Díaz M, Medina-Bañuelos EF, Salgado-Cruz MP, Marín-Santibáñez BM, García-Hernández AB, Gómez-Gómez AL, Hernández-Martínez DM.   +6 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source