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Hyaluronan: Metabolism and Function
Biomolecules, 2020 As a major polysaccharide component of the extracellular matrix, hyaluronan plays essential roles in the organization of tissue architecture and the regulation of cellular functions, such as cell proliferation and migration, through interactions with ...
Takashi Kobayashi +2 more
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Nature Communications, 2020 Bioproduction of hyaluronan needs increases in yield and greater diversity of the molecular weights. Here, the author increases hyaluronan production and diversifies the molecular weights through engineering the hyaluronan biosynthesis pathway and ...
Yang Wang +7 more
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Gut Microbes, 2021 Hyaluronan is a glycosaminoglycan polymer that has been shown to play an important role in homeostasis of the gastrointestinal tract. However, its mechanistic significance in gastrointestinal epithelial barrier elements remain unexplored.
Tangyou Mao +8 more
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Roles of glomerular endothelial hyaluronan in the development of proteinuria
Physiological Reports, 2021 Vascular endothelial cells are covered with glycocalyx comprising heparan sulfate, hyaluronan, chondroitin sulfate, and associated proteins. Glomerular endothelial glycocalyx is involved in protecting against induction of proteinuria and structural ...
Akimasa Asai +15 more
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Chemical Modification of Hyaluronan and Their Biomedical Applications
Frontiers in Chemistry, 2022 Hyaluronan, the extracellular matrix glycosaminoglycan, is an important structural component of many tissues playing a critical role in a variety of biological contexts.
Vera Hintze +2 more
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Immunity, 2018 SUMMARY The maintenance of appropriate arterial tone is critically important for normal physiological arterial function. However, the cellular and molecular mechanisms remain poorly defined.
Shweta Tikoo +2 more
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Hyaluronan: Sources, Structure, Features and Applications
MoleculesHyaluronan (HA) is a non-sulfated glycosaminoglycan that is present in a variety of body tissues and organs. Hyaluronan has a wide range of biological activities that are frequently influenced by molar mass; however, they also depend greatly on the ...
Katarína Valachová +2 more
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Clinical Pregnancy Outcomes Following Blastocyst Transfer Using Media with Different Hyaluronan Concentrations:
LifeBackground and Objectives: Hyaluronan-enriched embryo transfer media have been proposed to improve implantation and reproductive outcomes; however, their clinical benefit remains uncertain, particularly in frozen embryo transfer cycles.
Mustafa Kemal Özel +3 more
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The Where, When, How, and Why of Hyaluronan Binding by Immune Cells
Frontiers in Immunology, 2015 Hyaluronan is made and extruded from cells to form a pericellular or extracellular matrix (ECM) and is present in virtually all tissues in the body. The size and form of hyaluronan present in tissues is indicative of a healthy or inflamed tissue, and the
Kelly L Brown +2 more
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Synaptic Hyaluronan Synthesis and CD44-Mediated Signaling Coordinate Neural Circuit Development
Cells, 2021 The hyaluronan-based extracellular matrix is expressed throughout nervous system development and is well-known for the formation of perineuronal nets around inhibitory interneurons.
Emily S. Wilson, Karen Litwa
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