Results 11 to 20 of about 82,581 (251)

Targeting Hyaluronan Synthesis in Cancer: A Road Less Travelled

Biologics, 2023
Hyaluronan is one of the major components of the extracellular matrix and is involved in the regulation of multiple processes in both human physiology and disease.
Theodoros Karalis
doaj   +1 more source

Structure, substrate-recognition, and initiation of hyaluronan synthase

Nature, 2022
Hyaluronan is an acidic heteropolysaccharide comprising alternating N-acetylglucosamine and glucuronic acid sugars that is ubiquitously expressed in the vertebrate extracellular matrix1.
F. Maloney, Jeremi Kuklewicz, R. Corey, Y. Bi, Ruo-Ya Ho, L. Mateusiak, E. Pardon, J. Steyaert, P. Stansfeld, J. Zimmer   +9 more
semanticscholar   +1 more source

CD44-mediated hyaluronan binding marks proliferating hematopoietic progenitor cells and promotes bone marrow engraftment. [PDF]

PLoS ONE, 2018
CD44 is a widely expressed cell adhesion molecule that binds to the extracellular matrix component, hyaluronan. However, this interaction is not constitutive in most immune cells at steady state, as the ability of CD44 to engage hyaluronan is highly ...
Sally S M Lee-Sayer, Meghan N Dougan, Jesse Cooper, Leslie Sanderson, Manisha Dosanjh, Christopher A Maxwell, Pauline Johnson   +6 more
doaj   +1 more source

The Degradation of Hyaluronan in the Skin

Biomolecules, 2022
Hyaluronan (HA) comprises a fundamental component of the extracellular matrix and participates in a variety of biological processes. Half of the total amount of HA in the human body is present in the skin. HA exhibits a dynamic turnover; its half-life in
P. Zadnikova, Romana Šínová, Vojtěch Pavlík, Matěj Šimek, B. Šafránková, M. Hermannová, K. Nešporová, V. Velebný   +7 more
semanticscholar   +1 more source

Hyaluronan export through plasma membranes depends on concurrent K+ efflux by K(ir) channels. [PDF]

PLoS ONE, 2012
Hyaluronan is synthesized within the cytoplasm and exported into the extracellular matrix through the cell membrane of fibroblasts by the MRP5 transporter.
Daniel Hagenfeld, Beatrice Borkenhagen, Tobias Schulz, Hermann Schillers, Udo Schumacher, Peter Prehm   +5 more
doaj   +1 more source

Randomized Phase III Trial of Pegvorhyaluronidase Alfa With Nab-Paclitaxel Plus Gemcitabine for Patients With Hyaluronan-High Metastatic Pancreatic Adenocarcinoma

Journal of Clinical Oncology, 2020
PURPOSE To evaluate the efficacy and safety of pegvorhyaluronidase alfa (PEGPH20) plus nab-paclitaxel/gemcitabine (AG) in patients with hyaluronan-high metastatic pancreatic ductal adenocarcinoma (PDA).
E. Van Cutsem, M. Tempero, D. Sigal, D. Oh, N. Fazio, T. Macarulla, E. Hitre, P. Hammel, A. Hendifar, S. Bates, Chung-Pin Li, S. Hingorani, C. de la Fouchardiére, A. Kasi, V. Heinemann, A. Maraveyas, N. Bahary, L. Layos, V. Sahai, Lei Zheng, J. Lacy, Joonoh Park, F. Portales, P. Oberstein, Wilson Wu, D. Chondros, A. Bullock   +26 more
semanticscholar   +1 more source

Hyaluronan nanoscale clustering and Hyaluronan synthase 2 expression are linked to the invasion of child fibroblasts and infantile fibrosarcoma in vitro and in vivo

Scientific Reports, 2022
Infantile fibrosarcoma is a rare childhood tumour that originates in the fibrous connective tissue of the long bones for which there is an urgent need to identify novel therapeutic targets.
Joseph J. Tonge, Scott V. Notley, Mark J. Dunning, Ana López-Guajardo, Jessica D. Medcalf, Paraskevi Heldin, George Panoutsos, Annica K. B. Gad   +7 more
doaj   +1 more source

Biocompatible topical delivery system of high-molecular-weight hyaluronan into human stratum corneum using magnesium chloride

Scientific Reports, 2023
Non-invasive delivery of hyaluronan into the stratum corneum (SC) is extremely difficult because of its high molecular weight and the strong barrier of the SC.
Mika Y. Fujii, Anna Okishima, Hiroko S. Ichiwata, Takashi Oka   +3 more
doaj   +1 more source

Hyaluronan and the Fascial Frontier

International Journal of Molecular Sciences, 2021
The buzz about hyaluronan (HA) is real. Whether found in face cream to increase water volume loss and viscoelasticity or injected into the knee to restore the properties of synovial fluid, the impact of HA can be recognized in many disciplines from ...
Rebecca L Pratt
semanticscholar   +1 more source

Endogenous production of hyaluronan, PRG4, and cytokines is sensitive to cyclic loading in synoviocytes.

PLoS ONE, 2022
Synovial fluid is composed of hyaluronan and proteoglycan-4 (PRG4 or lubricin), which work synergistically to maintain joint lubrication. In diseases like osteoarthritis, hyaluronan and PRG4 concentrations can be altered, resulting in lowered synovial ...
Meghana Pendyala, Paige S Woods, Douglas K Brubaker, Elizabeth A Blaber, Tannin A Schmidt, Deva D Chan   +5 more
doaj   +2 more sources