Extracellular Matrix Mimics Using Hyaluronan-Based Biomaterials.
Trends in Biotechnology, 2020 Hyaluronan (HA) is a critical element of the extracellular matrix (ECM). The regulated synthesis and degradation of HA modulates the ECM chemical and physical properties that, in turn, influence cellular behavior.
S. Amorim, C. Reis, R. Reis, R. Pires
semanticscholar +1 more source
Chlorination and oxidation of heparin and hyaluronan by hypochlorous acid and hypochlorite anions: effect of sulfate groups on reaction pathways and kinetics. [PDF]
, 2013 Hypochlorous acid (HOCl), produced in inflammatory conditions by the enzyme myeloperoxidase, and its anion hypochlorite (OCl(-)) exist in vivo at almost equal concentrations.
Parsons, BJ +4 more
core +1 more source
MCF10CA Breast Cancer Cells Utilize Hyaluronan-Coated EV-Rich Trails for Coordinated Migration
Frontiers in Oncology, 2022 Invasion of tumor cells through the stroma is coordinated in response to migratory cues provided by the extracellular environment. One of the most abundant molecules in the tumor microenvironment is hyaluronan, a glycosaminoglycan known to promote many ...
Niina Aaltonen +7 more
doaj +1 more source
Hyaluronan: molecular size‐dependent signaling and biological functions in inflammation and cancer
The FEBS Journal, 2019 Hyaluronan (HA) is a linear nonsulfated glycosaminoglycan of the extracellular matrix that plays a pivotal role in a variety of biological processes.
A. Tavianatou +5 more
semanticscholar +1 more source
Endothelial glycocalyx impairment in disease: Focus on hyaluronan shedding.
American Journal of Pathology, 2020 Hyaluronan (HA) is a ubiquitous glycosaminoglycan of the extracellular matrix. It is present in the endothelial glycocalyx covering the apical surface of endothelial cells.
S. Dogné, B. Flamion
semanticscholar +1 more source
Inter-α-Inhibitor Impairs TSG-6-Induced Hyaluronan Cross-Linking [PDF]
, 2013 Under inflammatory conditions and in the matrix of the cumulus-oocyte complex (COC), the polysaccharide hyaluronan (HA) becomes decorated covalently with heavy chains (HCs) of the serum glycoprotein inter-α-inhibitor (IαI).
Briggs, David C. +17 more
core +1 more source
Mycobacteria exploit host hyaluronan for efficient extracellular replication. [PDF]
PLoS Pathogens, 2009 In spite of the importance of hyaluronan in host protection against infectious organisms in the alveolar spaces, its role in mycobacterial infection is unknown.
Yukio Hirayama +11 more
doaj +1 more source
Hepatology, EarlyView., 2022 Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid +20 more
wiley +1 more source
Importance of hyaluronan biosynthesis and degradation in cell differentiation and tumor formation
Brazilian Journal of Medical and Biological Research, 2003 Hyaluronan is an important connective tissue glycosaminoglycan. Elevated hyaluronan biosynthesis is a common feature during tissue remodeling under both physiological and pathological conditions.
P. Heldin
doaj +1 more source
Hyaluronan and Its Interactions With Immune Cells in the Healthy and Inflamed Lung
Frontiers in Immunology, 2018 Hyaluronan is a hygroscopic glycosaminoglycan that contributes to both extracellular and pericellular matrices. While the production of hyaluronan is essential for mammalian development, less is known about its interaction and function with immune cells.
Pauline Johnson +3 more
doaj +1 more source