Results 151 to 160 of about 2,242,520 (263)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
DFRL-Mol: a dual-stage framework of reinforcement learning for multi-scenario molecule optimization. [PDF]
Brief BioinformWu Z +7 more
europepmc +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
A unified solvatochromic-computational-machine-learning approach for solvent property prediction based on iodine color response. [PDF]
Chem SciGordeev EG +5 more
europepmc +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
An Automated Tool for Predicting Ion-Molecule Reaction Rates in CI-MS: Application to PCDDs and PCDFs. [PDF]
J Mass SpectromBhatia M.
europepmc +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
WGM Single-Molecule Validation of pH-Dependent Molecular Energetics at Gold Nanointerfaces: Influence of Buffer Molecules on Glyphosate Ligand Binding. [PDF]
Adv Sci (Weinh)Perera KMK +3 more
europepmc +1 more source
, 2013 O recurso simula o modelo em 3D de algumas moléculas, suas possíveis ligações, geometria molecular e eletrônica, além de ressaltar o efeito da repulsão eletrônica entre os pares de elétrons não ligantes na geometriaEnsino Médio::QuímicaEducação Superior::
Chamberlain, Julia +4 more
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