Results 131 to 140 of about 2,242,520 (263)
Scientific ReportsThe human antibody repertoire is a promising source for therapeutic-grade antibodies. Yet current methods for strategically mining these B cell repertoires are stymied by throughput and chain pairing considerations.
Anusuya Ramasubramanian +24 more
doaj +1 more source
Introduction to single molecule analysis and computation: the FOCUS Project
, 2014 The FP7 project FOCUS “Single-molecule activation and detection” belongs to the FET Proactive 7 Programme: “Molecular Scale Devices and Systems” and is aimed at investigating and developing molecular devices (MD) where single molecules become computing ...
Vincent Torre +3 more
core +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
, 2016 O recurso simula o modelo em 3D de algumas moléculas, suas possíveis ligações, geometria molecular e eletrônica, além de ressaltar o efeito da repulsão eletrônica entre os pares de elétrons não ligantes na geometriaEnsino Médio::QuímicaEducação Superior::
Chamberlain, Julia +4 more
core +2 more sources
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Single-molecule characterization of topological polymer dynamics
, 2018 Topological polymers such as ring polymers often display unexpected static and dynamic behaviors, and thus could contribute to the development of new polymer materials through a topology-directed control of the rheological properties.
Habuchi, Satoshi
core
Mutations in the extracellular domain of the neural cell adhesion molecule L1 impair protein trafficking in vitro and in vivo [PDF]
, 2002 Rünker AE. Mutations in the extracellular domain of the neural cell adhesion molecule L1 impair protein trafficking in vitro and in vivo. Bielefeld (Germany): Bielefeld University; 2002.Das neurale Zelladhäsionsmolekül L1 ist ein Mitglied der ...
Rünker, Annette E.
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source