Results 111 to 120 of about 2,242,520 (263)
DeSci EDU: course design and self-perceived evaluation in decentralized science education
Frontiers in BlockchainIntroductionDecentralized science (DeSci) aims to address structural inefficiencies in traditional research yet lacks formal educational pathways.MethodsThis exploratory case study develops and evaluates an eight-week blended course, DeSci EDU, which ...
S. Espinoza +8 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Targeted dual selection to optimize transposon stable pool generation of multispecifics
mAbsGrowing knowledge around disease states has led to opportunities within research to make designer molecules with improved specificity and broader efficacy.
Julie Johnston +9 more
doaj +1 more source
, 2019 Here we report molecular films terminated with diazonium salts moieties at both ends which enables single-molecule contacts between gold and silicon electrodes at open circuit via a radical reaction.
Yan B Vogel (23524978) +7 more
core
, 2018 The first tetranuclear metallacage and mononuclear cocrystalline DyIII-radical complex was synthesized and characterized. The metallacage in [Dy4(hfac)8(IMPhThio)2(OH)4][Dy(hfac)3(NITPhThio)2] consists of Dy(hfac)2+ groups bridged by OH– and the ...
Li Tian (207552) +11 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Advanced ScienceBuried‐interface engineering has emerged as a central strategy for advancing the efficiency and stability of halide perovskite solar cells. Bathocuproine (BCP) and its derivatives have been employed as ultrathin insulating interlayers that modulate ...
Dong Hyun Kim +9 more
doaj +1 more source
Frontiers in Bioengineering and BiotechnologyIntroductionCodon optimization is utilized in biologics design to maximize protein expression. Selecting the host organism’s most frequently used codons for each amino acid can significantly enhance recombinant protein expression yields.
Timothy Z. Chang +10 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source