Results 121 to 130 of about 2,067,232 (315)
, 2019 Although organic small-molecule-based memory devices (OSMDs) have been demonstrated to show great potential for the application in next-generation data-storage technology, progress toward their further development has been hugely hindered by the ...
Chunlan Ma (7517306) +7 more
core +1 more source
DeSci EDU: course design and self-perceived evaluation in decentralized science education
Frontiers in BlockchainIntroductionDecentralized science (DeSci) aims to address structural inefficiencies in traditional research yet lacks formal educational pathways.MethodsThis exploratory case study develops and evaluates an eight-week blended course, DeSci EDU, which ...
S. Espinoza +8 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Binary Drug Reinforced First Small-Molecule-Based Prodrug for Synergistic Anticancer Effects
, 2019 We developed a small-molecule-based binary drug delivery system (BDDS) with two anticancer drugs, SN-38 and 5′-DFUR. The drug release from the prodrug BDDS can be achieved upon its reaction with intracellular H2O2, overexpressed in cancer cells.
Paramesh Jangili +15 more
core +1 more source
Targeted dual selection to optimize transposon stable pool generation of multispecifics
mAbsGrowing knowledge around disease states has led to opportunities within research to make designer molecules with improved specificity and broader efficacy.
Julie Johnston +9 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
, 2018 The first tetranuclear metallacage and mononuclear cocrystalline DyIII-radical complex was synthesized and characterized. The metallacage in [Dy4(hfac)8(IMPhThio)2(OH)4][Dy(hfac)3(NITPhThio)2] consists of Dy(hfac)2+ groups bridged by OH– and the ...
Li Tian (207552) +11 more
core +1 more source
Frontiers in Bioengineering and BiotechnologyIntroductionCodon optimization is utilized in biologics design to maximize protein expression. Selecting the host organism’s most frequently used codons for each amino acid can significantly enhance recombinant protein expression yields.
Timothy Z. Chang +10 more
doaj +1 more source
Nature Communications, 2016 In response to intracellular signals, bacterial translational riboswitches embedded in mRNAs can regulate gene expression through inhibition of translation initiation.
Arlie J. Rinaldi +3 more
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Nature, 1922 DIRECT evidence that the molecules of gases are not spherically symmetrical and are anisotropic in their properties is furnished by the recent experiments of Lord Rayleigh, who has shown that the light scattered by molecules is, in general, not completely polarised when observed in a direction transverse to the pencil of light traversing the gas.
openaire +1 more source