Results 121 to 130 of about 1,670,637 (256)
DeSci EDU: course design and self-perceived evaluation in decentralized science education
Frontiers in BlockchainIntroductionDecentralized science (DeSci) aims to address structural inefficiencies in traditional research yet lacks formal educational pathways.MethodsThis exploratory case study develops and evaluates an eight-week blended course, DeSci EDU, which ...
S. Espinoza +8 more
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Nature, 1922 DIRECT evidence that the molecules of gases are not spherically symmetrical and are anisotropic in their properties is furnished by the recent experiments of Lord Rayleigh, who has shown that the light scattered by molecules is, in general, not completely polarised when observed in a direction transverse to the pencil of light traversing the gas.
openaire +1 more source
Targeted dual selection to optimize transposon stable pool generation of multispecifics
mAbsGrowing knowledge around disease states has led to opportunities within research to make designer molecules with improved specificity and broader efficacy.
Julie Johnston +9 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Non-Markovian full counting statistics in quantum dot molecules
, 2015 Full counting statistics of electron transport is a powerful diagnostic tool for probing the nature of quantum transport beyond what is obtainable from the average current or conductance measurement alone.
Jiao, Hu-Jun +3 more
core +1 more source
Frontiers in Bioengineering and BiotechnologyIntroductionCodon optimization is utilized in biologics design to maximize protein expression. Selecting the host organism’s most frequently used codons for each amino acid can significantly enhance recombinant protein expression yields.
Timothy Z. Chang +10 more
doaj +1 more source
Nature Communications, 2016 In response to intracellular signals, bacterial translational riboswitches embedded in mRNAs can regulate gene expression through inhibition of translation initiation.
Arlie J. Rinaldi +3 more
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Rapid affinity-based purification of multi-specific antibodies using Kappa Select and Protein L
mAbsMultispecific antibodies (msAbs) are becoming more prevalent as formats of choice for therapeutic antibody development due to their ability to modulate multiple biological targets.
Kalie Mix +6 more
doaj +1 more source