Results 191 to 200 of about 3,532,802 (344)

Hydrogen molecule in a magnetic field: The lowest states of theΠmanifold and the global ground state of the parallel configuration [PDF]

, 1998
T. Detmer, Peter Schmelcher, Lorenz S. Cederbaum   +2 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Long-Lasting, Fine-Tuned Anti-tumor Activity of Recombinant Listeria monocytogenes Vaccine Is Controlled by Pyroptosis and Necroptosis Regulatory and Effector Molecules

Abolaji Samson Olagunju, Andrew V. D. Sardinha, Gustavo P. Amarante‐Mendes   +2 more
openalex   +2 more sources

Never Draw the Same Molecule Twice - Writing PNG Image Metadata with Python

, 2007
Richard L. Apodaca
openalex   +1 more source

Capturing reaction paths and intermediates in Cre- loxP recombination using single-molecule fluorescence [PDF]

, 2012
Justin N. M. Pinkney, Paweł Zawadzki, Jarosław Mazuryk, Lidia K. Arciszewska, David J. Sherratt, Achillefs N. Kapanidis   +5 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Leukemia inhibitory factor increases the invasiveness of trophoblastic cells through integrated increase in the expression of adhesion molecules and pappalysin 1 with a concomitant decrease in the expression of tissue inhibitor of matrix metalloproteinases [PDF]

, 2012
Pankaj Suman, Nachiket Shembekar, Gupta Sk   +2 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Mechanistic Study of Diketopiperazine Formation during Solid-Phase Peptide Synthesis of Tirzepatide

ACS Omega, 2022
Jingyao Wang, Mark R. Berglund, Timothy Braden, Matthew C. Embry, Martin D. Johnson, Stephen R. Groskreutz, Fareed Bhasha Sayyed, Sergey Vladimirovich Tsukanov, Timothy D. White, Ankur Jalan, Kevin D. Seibert, Michael E. Kopach   +11 more
doaj   +1 more source

Mechanistic basis for relaxation of DNA supercoils by human topoisomerase IIIα-RMI1-RMI2. [PDF]

Proc Natl Acad Sci U S A
Spakman D, Biebricher AS, Bizard AH, Hickson ID, Peterman EJG, Wuite GJL, King GA.   +6 more
europepmc   +1 more source