Results 221 to 230 of about 3,841,010 (347)

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Normal Coordinate Treatment for the Out-of-Plane Vibrations of Ethylene-Type Molecules [PDF]

, 1956
Jerome M. Dowling
openalex   +1 more source

Elucidating structural and molecular requirements of somatostatin subtype-4 agonist bound complexes using quantum mechanics approaches.

Org Biomol Chem
Slater O, Kontoyianni M.
europepmc   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

FDA-approved small-molecule kinase inhibitors.

TIPS - Trends in Pharmacological Sciences, 2015
Peng Wu, T. Nielsen, M. Clausen
semanticscholar   +1 more source

Kinetics of the Decomposition of Molecules of Intermediate Complexity

, 1933
Cyril Norman Hinshelwood, C. J. M. Fletcher   +1 more
openalex   +1 more source

Prediction of Small-Molecule Partitioning into Biomolecular Condensates from Simulation. [PDF]

JACS Au
Emelianova A, Garcia PL, Tan D, Joseph JA.   +3 more
europepmc   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

Melatonin: an ancient molecule that makes oxygen metabolically tolerable

Journal of Pineal Research, 2015
L. Manchester, A. Coto-Montes, J. Boga, Lars Peter H. Andersen, Zhou Zhou, A. Galano, J. Vriend, D. Tan, R. Reiter   +8 more
semanticscholar   +1 more source

Studies on the antileukemic action of certain compounds related to moieties of the 4-amino-pteroylglutamic acid (aminopterin) molecule [PDF]

, 1950
Howard E. Skipper, Pradisth C. Edwards, Carl E. Bryan, Juanita B. Chapman, Martelia Bell, Olivia S. Hutchison   +5 more
openalex   +1 more source