Results 251 to 260 of about 5,474,193 (390)

Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.

open access: yesCancer Discovery, 2015
B. Seashore-Ludlow   +25 more
semanticscholar   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

open access: yesMolecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez   +5 more
wiley   +1 more source

The collision of electrons with molecules

open access: gold, 1932
H. S. W. Massey, C. B. O. Mohr
openalex   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee   +9 more
wiley   +1 more source

Revenue Differences Between Top-Selling Small-Molecule Drugs and Biologics in Medicare.

open access: yesJAMA Health Forum
Vogel M   +6 more
europepmc   +1 more source

FDA-approved small-molecule kinase inhibitors.

open access: yesTIPS - Trends in Pharmacological Sciences, 2015
Peng Wu, T. Nielsen, M. Clausen
semanticscholar   +1 more source

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