Results 131 to 140 of about 877,283 (253)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Versatile Control System for Automated Single-Molecule Optical Tweezers Investigations [PDF]

, 2010
We present a versatile control system to automate single-molecule biophysics experiments. This method combines low-level controls into various functional, user-configurable modules, which can be scripted in a domain-specific instruction language.
Steven J. Koch, Richard C. Yeh
core  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

UV‐Triggered Cascading Degradation of Silicone Elastomer via Self‐Fluoride Amplification

Advanced Science
UV‐triggered on‐demand degradable materials offering accurate and remote control of material lifetime, are emerging as vital element for applications such as self‐destructive soft robotics for hardware security, triggerable transient electronics, and ...
Yoon‐Nam Kim, Woojin Jeon, Min‐Ha Oh, Hee‐June Seo, Min Sang Kwon, Seung‐Kyun Kang   +5 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

ANNalog — Generation of MedChem-similar Molecules

Journal of Cheminformatics
Generative deep-learning models have demonstrated significant potential in designing drug-like molecules. However, medicinal chemistry typically requires generating analogues that combine structural similarity with scaffold hopping—the replacement of molecular scaffolds while retaining biological relevance.
Wei Dai, Jonathan D Tyzack, Arianna Fornili, Chris de Graaf, Noel M O’Boyle   +4 more
openaire   +1 more source

development of a Free-Piston Linear Generator for use in an Extended-Range Electric Vehicle [PDF]

, 2012
This paper presents the development methodology of the Free-Piston Linear Generator. The FPLG is a free-piston combustion engine with an integrated linear generator. The engine can be used as a range-extending device in an electric vehicle.
Friedrich, Horst E., Ferrari, Cornelius
core  

graphpancake: a Python package for representing organic molecules as molecular graphs utilizing electronic structure theory

Journal of Cheminformatics
Computational methods for predictive modeling have been increasingly utilized in the early stages of drug discovery to supplement high-throughput screening.
Sneha Sil, Mark A. Maskeri, Karl A. Scheidt   +2 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source